m-PEG-DSPE (methoxy polyethylene glycol-distearoylphosphatidyl ethanolamine) plays a key role in drug delivery and nanoparticle formulations. It combines a PEG chain with a DSPE lipid, which stabilizes nanoparticles and forms micelles. This design improves drug delivery by boosting biocompatibility and extending circulation time in the body.
m-PEG-DSPE
tures:
- Amphiphilic Structure: The combination of PEG and DSPE allows it to stabilize nanoparticles effectively. This structure makes it ideal for various drug delivery systems.
- Biocompatibility: Both PEG and DSPE are biocompatible, making it safe for pharmaceutical use.
- Stealth Properties: The PEG chain helps reduce protein adsorption and evades immune detection. This increases the circulation time of nanoparticles.
- Customizable PEG Length: You can adjust the PEG chain length based on specific applications, giving you control over particle size and biodistribution.
Applications:
- Drug Delivery: It is widely used in liposomal drug delivery, enhancing the stability and pharmacokinetics of medications.
- Nanoparticle Formulation: m-PEG-DSPE helps form stable micelles and nanoparticles, ideal for encapsulating hydrophobic drugs.
- Surface Modification: It coats nanoparticles and liposomes, improving biocompatibility and extending circulation time.
Benefits:
- Increased Stability: PEGylation boosts the stability of liposomes and nanoparticles, especially in biological environments.
- Prolonged Circulation: The PEG chain prevents rapid clearance by the immune system, ensuring efficient drug delivery.
Storage and Handling:
Store in a cool, dry place. Keep it away from light to maintain its stability and function.