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Hydroxy-PEG-CH2CO2tBu is a compound with functional groups that have been extensively used in drug research and development. This molecule belongs to the class of polyethylene glycol (PEG) derivatives and contains a hydroxyl group and a carboxylic acid group linked to a tert-butyl ester via a methylene group. These functional groups offer various advantages in drug development, including improved solubility, reduced toxicity, and enhanced pharmacokinetic properties.

Hydroxy-PEG-CH2CO2tBu has been widely used as a linker in drug conjugates, where it acts as a bridge between the therapeutic agent and a targeting moiety. The hydroxyl group of the molecule can be easily modified to introduce other functional groups, such as amines or carboxylic acids, to further improve its bioactivity and targeting ability.

Additionally, the tert-butyl ester group offers protection to the carboxylic acid, which can be easily removed under mild conditions to yield the free acid. This property makes Hydroxy-PEG-CH2CO2tBu a valuable building block in the synthesis of prodrugs, where the therapeutic agent is linked to a pro-moiety that is cleaved in vivo to release the active drug.


Cat# Name Structure M.W. Purity Pricing
AP10467HO-PEG1-CH2COOtBu176.21≥95% Pricing
AP10468HO-PEG2-CH2COOtBu220.26≥95% Pricing
AP10469HO-PEG3-CH2COOtBu264.32≥95% Pricing
AP10470HO-PEG4-CH2COOtBu308.37≥95% Pricing
AP10471HO-PEG5-CH2COOtBu352.42≥95% Pricing
AP10472HO-PEG6-CH2COOtBu396.47≥95% Pricing
AP10473HO-PEG7-CH2COOtBu440.53≥95% Pricing
AP10474HO-PEG8-CH2COOtBu484.57≥95% Pricing
AP10475HO-PEG10-CH2COOtBu572.67≥95% Pricing
AP10476HO-PEG12-CH2COOtBu660.77≥95% Pricing
AP10477HO-PEG24-CH2COOtBu1189.37≥95% Pricing

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