Folate-PEG-hydrazide（Folic Acid-PEG-hydrazide） is a versatile compound that has gained significant attention in drug research and development. This molecule consists of three functional groups: folate, PEG (polyethylene glycol), and hydrazide. The folate group provides targeting specificity to cancer cells, while the PEG group improves the solubility and pharmacokinetic properties of the drug. The hydrazide group allows for further modification through bioconjugation, enabling the attachment of drugs or imaging agents for targeted therapy or diagnostics.
Folate-PEG-hydrazide has been extensively studied as a drug delivery system for anticancer agents due to its ability to selectively target cancer cells that overexpress folate receptors. Moreover, the PEGylation of the compound can prolong its circulation time and reduce immunogenicity, making it an attractive option for drug delivery. The hydrazide group can be conjugated with a variety of drugs or imaging agents, allowing for customization of the drug delivery system to specific applications.