DBCO-amine & DBCO-PEG-amine are functional groups commonly used in drug research and development. These groups are often employed as linkers between drug molecules and other compounds or materials, such as nanoparticles or biomolecules, to enhance the drug’s properties and efficacy.
DBCO, or dibenzocyclooctyne, is a reactive cyclooctyne that forms a covalent bond with azides through a copper-free click reaction known as strain-promoted alkyne-azide cycloaddition (SPAAC). This reaction is highly selective and biocompatible, making DBCO-amine & DBCO-PEG-amine popular choices for bioconjugation and drug delivery applications.
The addition of a PEG (polyethylene glycol) chain to the DBCO-amine molecule allows for improved water solubility and biocompatibility. DBCO-PEG-amine can be used to modify drug molecules, enhance their pharmacokinetics, and reduce toxicity.
