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Bis-sulfone NHS ester is a functional group commonly used in drug research and development for the creation of biologically active compounds. This group contains two sulfone moieties connected by a carbon chain and a reactive NHS ester group, allowing for facile conjugation with primary amines. The resulting compounds can exhibit diverse biological activities and have potential applications in the treatment of various diseases.

Bis-sulfone NHS esters are classified as bifunctional crosslinkers due to their ability to covalently link two separate molecules. They are particularly useful in the development of targeted therapeutics, where the compound can be conjugated to a targeting agent such as an antibody or peptide to selectively deliver a drug payload to a specific cell or tissue type.

Additionally, the sulfone group in bis-sulfone NHS esters is known to exhibit antioxidant properties, making them potential candidates for the treatment of oxidative stress-related diseases such as Alzheimer’s and Parkinson’s. The use of bis-sulfone NHS esters in drug research and development has therefore garnered significant attention in recent years, with a growing interest in the synthesis and evaluation of novel bis-sulfone-based compounds.

Bis-sulfone NHS esters are a versatile functional group with diverse applications in drug research and development. Their ability to crosslink molecules and their potential antioxidant properties make them attractive candidates for the development of targeted therapeutics and the treatment of various diseases.

Bis-sulfone NHS Ester

Cat# Name Structure M.W. Purity Pricing
AP12583Bis-sulfone NHS Ester597.66≥95% Pricing
AP13034Bis-sulfone-PEG4-NHS ester844.95≥95% Pricing
AP13386Bis-sulfone-PEG8-NHS Ester1021.2≥95% Pricing
AP13387Bis-sulfone-PEG12-NHS Ester1197.4≥90% Pricing

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