Iodoacetamide-PEG-amine is a chemical compound that belongs to the class of PEGylation reagents. It is a functionalized molecule that contains an iodoacetamide group, which reacts with sulfhydryl (-SH) groups of cysteine residues in proteins, and a PEG-amine group, which imparts water solubility and biocompatibility to the compound. Iodoacetamide-PEG-amine has been extensively used in pharmaceutical research and development for site-specific modification of proteins, drug delivery, and bioconjugation. The modification of proteins using this compound enables the production of highly homogeneous protein conjugates, which have improved stability, solubility, and pharmacokinetic properties. Additionally, Iodoacetamide-PEG-amine has been used for the development of drug delivery systems, such as PEGylated liposomes and nanoparticles, which improve the delivery of drugs to target tissues and reduce toxicity.