How Linker Design Drives the Success of Antibody-Drug Conjugates (ADCs)
In the early stages of ADC development, researchers often overlooked linker design, thinking that adding...
18
Nov
How Linker Design Drives the Success of Antibody-Drug Conjugates (ADCs)
24
Oct
Comparison of Label-Free Protein Quantification in Saliva: Fusion Lumos vs. TimsTOF Pro2
Comparison of Label-Free Protein Quantification in Saliva: Fusion Lumos vs. TimsTOF Pro2
This comparison of Fusion Lumos a...
23
Oct
From Design to Degradation: The Essential Role of Linkers in PROTACs
PROTAC (Proteolysis Targeting Chimera) technology is revolutionizing drug development by targeting disease-causing proteins d...
19
Oct
Application of lipidomics in the diagnosis and treatment of tumors
Introduction to LipidomicsLipids play a crucial role in cancer biology, with changes in lipid metabolism commo...
17
Oct
What are Degrader Antibody Conjugates (DACs): How PROTACs are Transforming Targeted Therapy
What are Degrader Antibody Conjugates (DACs): How PROTAC PEGs are Transforming Targeted Therapy
Degrader Antibody Conjugates (DACs) ar...
17
Oct
Targeting Cancer: Discover the Power of Folate Receptor Chimeras (FRTAC) for Selective Degradation
Mechanism of Action
Folate Receptor Chimeras (FRTACs) are designed to leverage the strong binding of folate receptors (FRs) to folate c...
09
Oct
Glutamine Metabolism and Cancer Therapy: A Comprehensive Guide
Glutamine Metabolism and Cancer Therapy: A Comprehensive Guide
Glutamine metabolism plays a k...
09
Oct
Mastering Protein Purification: Your Essential Guide to Techniques, Tips, and Troubleshooting
Mastering Protein Purification: Your Essential Guide to Techniques, Tips, and Troubleshooting
Protein separatio...
08
Oct
How Bispecific Antibodies Like MCLA-158 are Changing Cancer Treatment with ADCs
A bispecific antibody (BsAb) is a type of engineered antibody that can bind two different antigens or epitopes simultaneously. With...
04
Oct
What is the Karl Fischer method?
Karl Fischer Titration: Accurate Moisture Measurement
Overview:
Karl Fischer (KF) titration, first introduced in 1935, remains ...
04
Oct
LC-MS Features and Applications
LC-MS: Key Features and Applications
Overview:
LC-MS (Liquid Chromatography-Mass Spectrometry) is a powerful technique that mer...
03
Oct
Comprehensive List of FDA-Approved Antibody-Drug Conjugates (ADCs) – Updated for 2024
Comprehensive List of FDA-Approved Antibody-Drug Conjugates (ADCs) – Updated for 2024
Overview:
Antibody-Drug Conjuga...
02
Oct
How does a Fluorescence Microscope Work?
Fluorescence Microscope Overview
A fluorescence microscope utilizes ultraviolet light to excite specimens, causing them to emit fluo...
02
Oct
Mastering Fluorescence Microscopy: A User-Friendly Guide to Top Dyes and Cutting-Edge Imaging Techniques
Fluorescence Microscopy: A Guide to Popular Dyes and Advanced Techniques
Fluorescence microscopy has revolutionized biological res...
02
Oct
What is potentiometric titration?
Potentiometric Titration Overview
Potentiometric titration finds the endpoint by measuring changes in electrical potential. Unli...
01
Oct
PEG Lipids: Enhancing Drug Delivery and Therapeutic Efficacy
What Are PEG Lipids?
PEG lipids, or PEGylated lipids, peg conjugated lipidsare polyethylene glycol (P...
30
Sep
GC-MS, LC-MS, LC-MS/MS, HPLC, and UPLC: Key Analytical Techniques Explained
GC-MS, LC-MS, LC-MS/MS, HPLC, and UPLC: Key Analytical Techniques Explained
Overview
GC-MS, LC-MS, LC-MS/MS, HPLC, and UPLC are pow...
26
Sep
Ion Exchange Chromatography: A Comprehensive Guide
Ion Exchange Chromatography (IEX Chromatography) is a powerful and widely used separation technique that separates ions and p...
26
Sep
Mass Spec for Protein Analysis: Techniques, Applications, and Benefits
Mass Spectrometry for Protein Analysis: Techniques, Applications, and Benefits
Mass spectrometry (MS) has become an indispensable tool...
25
Sep
Oxime and Hydrazone Reactions in Bioconjugation [with Top 10 most Asked Questions About Oxime and Hydrazone Reactions]
Oxime and Hydrazone Reactions: Essential Tools in Bioconjugation
Introduction
Oxime and hydrazone reactions are widely used in biocon...
25
Sep
Mass Spectrometry Revolution: Explore Its Impact from Lab to Life
Mass Spectrometry Revolution: Explore Its Impact from Lab to Life
Introduction
Mass spectrometry (MS) measures the mass-to-charge ratio...
24
Sep
What Are Glycolipids
Glycolipids: Key Players in Cell Biology and Therapeutics
Overview
Glycolipids are essential components of l...
24
Sep
Mastering Maleimide Reactions in Bioconjugation: Your Ultimate Hands-On Guide
Overview
The maleimide reaction, particularly the thiol-maleimide reaction, is a cornerstone of bioconjugation, commonly used ...
24
Sep
PEG Linkers Explained: Types, Uses, and Why They Matter in Bioconjugation
PEG Linkers: Versatile Tools for Bioconjugation and Drug Delivery
PEG (Polyethylene Glycol) linkers are essential components in the fi...
24
Sep
Fluorescent Dyes: Lighting Up Science and Medicine
What Are Fluorescent Dyes?
Fluorescent dyes, also known as fluorophores or fluo dyes, absorb light at one wavele...
19
Sep
Alkyne Azide Click Chemistry Protocol for ADC Bioconjugation with Real Examples
The Alkyne-Azide Click Chemistry protocol, also known as Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC)...
18
Sep
Comprehensive Statistical Analysis of Phosphoramidites: Market Trends, Applications, and Innovations
Interactive Table of Contents
17
Sep
12 most commonly asked questions about phosphoramidites
Commonly Asked Questions About Phosphoramidites
1. What are phosphoramidites used for?
Phosphoramidites are the building blocks for...
14
Sep
Complete Guide to Choosing the Right Cell Viability Assay
body { font-family: Arial, sans-serif; line-height: 1.6; margin: 0; pad...
13
Sep
Ultimate Guide to Choosing the Right Lipids for Drug Delivery and Formulation
Ultimate Guide to Choosing the Right Lipids for Drug Delivery and Formulation
Selecting the right lipids is essential for optimizing d...
10
Sep
Comprehensive Guide for Surface Modification Protocols with Chemical Linkers
Comprehensive Surface Modification Protocols with Chemical Linkers
Surface modification with chemical linkers i...
06
Sep
Lab Space Available
Looking for a cost-effective, innovation-ready lab space to grow your biotech venture?
...
03
Sep
PDC: A Complement to ADC or a New Frontier?
Exploring new types of drugs is a continuous endeavor in the pharmaceutical industry. After small molecules consi...
02
Sep
Eight Crucial Techniques in Chemical Composition Analysis
Chemical composition analysis is fundamental to understanding the structure, properties, and quality of materials in various scientific...
27
Aug
Ultimate Guide to Choosing the Right Biotin PEG Linker
Introduction
Biotin PEG linkers are essential tools in biochemical research and biotechnology for conjugating biotin to proteins, pe...
19
Aug
Ultimate Guide to Choosing the Right Cleavable Linker for ADCs
Antibody-drug conjugates (ADCs) are sophisticated therapeutic agents designed to target and kill cancer cells while minimizing damage t...
04
Aug
Understanding ADCs: An Introduction to Targets
ADC (Antibody-Drug Conjugates) are targeted drugs composed of antibodies, linkers, and cytotoxic drugs. They use ...
04
Aug
Chemistry in Pictures: A Vibrant Discovery of Tetrazine Amine Compound by Axispharm Scientist
In the bustling labs of AxisPharm in San Diego, a surprising and visually striking discovery was made by scientis...
12
Jul
Protocol for PEG NHS Reagents
PEG NHS Ester is an amine-reactive reagent with a PEG spacer of specified length. It dissolves in organic solven...
11
Jul
Unlocking the Power of AOCs: How Antibody-Oligonucleotide Conjugates Are Shaping the Future of Precision Medicine
The Rise of Antibody-Oligonucleotide Conjugates (AOCs)
In the past decade, Antibody-Drug Conjugates (ADCs) have...
04
Jul
Protocol for PEG Acid Reagents
PEG acid is a type of PEG compound that features a carboxylic acid group at one end and can have a hydroxyl, azid...
02
Jul
An Introduction to Linkers in Antibody-Drug Conjugates (ADCs)
Antibody-drug conjugates (ADCs) are “biological bullets” that combine cytotoxic drugs (payloads) with antibodies ...
27
Jun
ADC Drugs Already Marketed Globally: Compilation of Technical Reviews
ADC (Antibody Drug Conjugate) is a complex that connects cytotoxic drugs to monoclonal antibodies targeting tumor...
17
Jun
A Comprehensive Introduction to Bispecific ADCs
Antibody-drug conjugates (ADCs) consist of an antibody, a linker, and a cytotoxic payload. Compared to traditiona...
11
Jun
AxisPharm Is Highlighted among Companies for Metabolomic and Proteomic Analysis Services
AxisPharm is mentioned in an NLM research paper among companies offering commercial products for metabolomic and ...
10
Jun
ADC Conjugation Technologies
This article introduces conjugation technologies based on carbonyl, amide, azido, and other amino acid funct...
06
Jun
Advances in ADC Linker Research
Due to improvements in payloads, linkers, and conjugation methods, antibody-drug conjugates (ADCs) have seen sign...
05
Jun
AxisPharm Is Listed as One of the Top Bioconjugation Companies
AxisPharm, a chemistry technology company, has a team of highly skilled synthetic organic chemists with exte...
29
May
Cleavable Linkers Play a Pivotal Role in the Success of Antibody-Drug Conjugates (ADCs)
Cleavable linkers used in ADC development can release drugs under specific conditions, such as changes in pH, th...
22
May
Next-Generation of Novel Antibody-Drug Conjugates: Click Chemistry ADCs
Currently, ADCs used in clinical settings mostly rely on effective internalization and transport to intracellular...
20
May
The High Hydrophilicity of ADC Linker Has Become the Main Trend in Modification
Founded in 2018, ProfoundBio originated in Seattle, Washington, USA. The three core founders are Dr. Baiteng Zhao...
13
May
Analysis of Multiple Factors Influencing ADC Pharmacokinetics
Antibody-drug conjugates (ADCs) are complex molecules wherein monoclonal antibodies are linked to cytotoxic drugs...
08
May
What is BCN：A Versatile Bioconjugation Tool
The BCN moiety is a strained cyclooctyne, which can react selectively with azide groups to form a stable triazole...
05
May
Challenges in Antibody-Drug Conjugate (ADC) Development
The next generation of ADCs employs enhanced strategies to achieve optimal stability and specificity, thereby imp...
27
Apr
ADC: All You Need to Know About Targeting, Termination, Optimization, and Phase II/III Clinical Trials
After decades of development, ADC drugs have entered a mature stage, with 15 ADCs approved globally and several A...
23
Apr
XDC | Various New Drug Conjugates, In Addition to ADC, There Are More Choices.
With the continuous development of technology, the boundaries of drug conjugates are constantly expanding. Throug...
01
Apr
ADC to XDC, Five Major Elements of Antibody Conjugate Drugs, Exploring the Fundamental Source of Innovation
From ADC to XDC, the future trend of conjugated drugs will focus on new target antigens, payloads with new mechan...
21
Mar
The Ultimate Guide to Fluorescent Dye
Fluorescent dyes, also known as fluorophores, are compounds that absorb light at one wavelength and emit light at...
17
Mar
Click Chemistry: The Go-To Toolkit for Fast and Efficient Reactions
Click Chemistry: The Go-To Toolkit for Fast and Efficient Reactions
What is Click Chemistry?
Click chemistry is ...
25
Jan
What is BiotinylationProtein？
Chemical Methods of Protein Biotinylation
Protein biotinylation, a vita...
25
Sep
What are Ionizable Lipids?
Ionizable Lipids Overview
Ionizable lipids are lipid molecules that stay neutral at normal physiological pH but...
25
Sep
What are Cationic Lipids?
Cationic lipids belong to a group of lipid molecules characterized by a permanently positively charged head group...
02
Jul
Agilent 1290 Infinity UPLC/ AB Sciex 5500 Qtrap Mass Spectrometer
Agilent 1290 Infinity UPLC/ AB ...
28
Jun
Polyethylene Glycol Classification
The Ultimate Guide to Polyethylene Glycol (PEG): Classification, Properties, and Applications
Polyethylene Glyc...
20
Jun
Solid Lipid Nanoparticles (SLNs)
Solid lipid nanoparticles (SLNs) have emerged as a promising drug delivery system due to their various advantage...
19
Jun
In Vitro vs In Vivo Studies of Polyethylene Glycol (PEG) Linkers
Polyethylene glycol (PEG) molecules have been used extensively as linkers in drug development, mainly due to thei...
04
Jun
What Are the Current Challenges in Bio Analytical Services
Bioanalytical services play a critical role in drug discovery and development. Despite the considerable progress...
22
May
Why Human epidermal growth factor receptor 2 (HER2) is an attractive target for ADC
HER2 (Human Epidermal Growth Factor Receptor 2) is a protein that ...
10
Feb
What is the difference between ADC linker and PEG linker?
Linkers are molecules used to connect two different molecules together to form a larger, more complex structure. They are used in many ...
09
Feb
Application of PEG Linker
A PEG (polyethylene glycol) linker is a chemical compound that is used to connect two or more molecules together. PEG is a water-solubl...
08
Feb
Importance of BA/BE studies in drug development
Bioavailability and bioequivalence (BA/BE) studies are essential components of the drug development process. By testing the rate and ex...
04
Feb
Protein Precipitation Technical Guide
Protein Precipitation: A Guide
Protein precipitation is a method used to separate proteins from other substances in a sample. This p...
10
Jan
Application of fluorescent dye labeling method
Introduction
Fluorescent dye labeling is a widely used technique in a variety of fields such as biology, biochemistry, and pharmacolog...
03
Jan
Main uses of cyanine dyes
Cyanine dyes are valuable organic compounds widely used in biotechnology, molecular biology, and imaging. Known for their bright fl...
22
Dec
Fluorescent dye dyeing principle
Fluorescent dyes are a type of dye that absorbs light at one wavelength and then re-emits it at a longer wavelength, which is why they ...
20
Dec
The role of proportionality in ascending dose studies
Proportionality refers to the relationship between the dose of a drug and its effect on the body. In the context of ascending dose stud...
14
Dec
Analysis method of Single Dose PK
Single dose pharmacokinetics (PK) is the study of how the body absorbs, distributes, metabolizes, and excretes a single dose of a drug....
08
Dec
How to choose the right fluorescent dye?
The difference between the main excitation light of the fluorescence and the main peak of the emission spectrum is called the stokes sh...
05
Dec
Analysis of advantages and disadvantages of fluorescent dye method and probe method
1. Fluorescent dye method (SYBR Green)
The principle is: to add excess fluorescent dye to the PCR reaction system, during the process ...
03
Dec
ADME Pharmacokinetic Testing Services
ADME is the abbreviation of "Absorption, Distribution, Metabolism, and Excretion" of a drug, which represents the process of the body's...
22
Nov
Intrinsic relationship of PK/PD study
Pharmaeokineties, PK: Absorption, distribution, metabolism and excretion of drugs in the body and their time course.
Pharmacodynanfics,...
15
Nov
What is fluorescence quenching?
Fluorescence Quenching: Understanding, Mechanisms, and Applications
Fluorescence quenching is a critical c...
14
Nov
What is biotinylation?
Biotinylation: Techniques and Applications
Introduction
Biotinylation is the process of attaching biotin to proteins, pep...
12
Nov
In vitro ADME research methods and analysis and measurement items
The metabolic properties of a compound are an important factor related to whether it can be turned into a drug and actually used in the...
11
Nov
What are the ingredients of a COVID-19 vaccine?
What is an mRNA vaccine? Like other types of vaccines, mRNA vaccines work by activating our own immune response, so that our bodies pro...
10
Nov
The Importance of Polyethylene Glycol (PEG) to the Pharmaceutical Industry
Polyethylene glycol (PEG) is a safe, inactive, and nontoxic polymer that is commonly used for molecular modification. Therapeutic benef...
09
Nov
Technical characteristics of PROTAC technology in drug research and development
Most of the drugs currently in clinical use are based on small molecules and use an "occupancy-driven" mode of action to inhibit the fu...
08
Nov
What is SPDP Crosslinker?
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive grou...
07
Nov
What is SPAAC?
2022 Nobel Prize in Chemistry: Revolutionizing Click Chemistry and Bioorthogonal Chemistry
In 2022, Carolyn Bertozzi, Morten Mel...
05
Nov
Difference Between Polymer PEG (Polydisperse PEG) and Monodisperse PEG
The polymer PEG is a polyethylene glycol (PEG) polymer, a polyether compound derived from petroleum that has many applications ranging ...
05
Nov
Why is blood-to-plasma ratio measurement important?
The blood-to-plasma ratio is important for understanding and predicting the concentration of a drug in the blood, and the blood-to-plas...
04
Nov
What is polyethylene glycol (PEG) modification?
Polyethylene glycol (PEG) modification is a polyethylene glycol with functional groups, which is mainly used for protein drug modificat...
03
Nov
Omics techniques for protein-protein interactions
To probe the molecular mechanisms of biological processes, it is necessary to identify the protein-protein interactions that mediate th...
02
Nov
What is immunoelectrophoresis?
Immunoelectrophoresis is a qualitative method that combines agar electrophoresis and two-dimensional agar diffusion for analyzing antig...
01
Nov
Experimental principle and steps of PI single staining method
The principle of PI single staining is mainly based on the characteristic changes that occur at the cellular, subcellular and molecular...
31
Oct
What is bioconjugation technology?
Bioconjugates are those involving one molecule attached to another molecule, often by covalent bonds, to create a complex consisting of...
29
Oct
Characteristics of 5 kinds of fluorescent dyes commonly used in nucleic acid detection
Nucleic acid fluorescent dyes stain the nucleus and quantitatively measure the fluorescence intensity of the cell, so that the content ...
28
Oct
What are ADC Linkers?
Antibody-drug conjugates (ADCs) are the most popular chemoimmunotherapy agents in recent years. ADCs can enhance the ability to target ...
27
Oct
What is immunocolloidal gold technology?
Colloidal gold is a commonly used labeling technology. It is a new type of immunolabeling technology that uses colloidal gold as a trac...
26
Oct
What are oligonucleotides?
Oligonucleotides are usually composed of short chains of nucleotides (deoxyribonucleotides or ribonucleotides) within 20, which can be ...
25
Oct
What is Blood Plasma Ratio?
Blood Plasma Ratio (BP) is one of the important parameters to measure the distribution of drugs from blood to tissues and organs, that ...
24
Oct
Methods for the determination of Plasma Concentration
Plasma Concentration refers to the total concentration of drugs in plasma after absorption, including drugs bound to plasma proteins or...
22
Oct
Application of Fluorescent Probes
Introduction to fluorescent probes:
After being excited by the excitation light, it returns to the ground state from the excited state ...
21
Oct
Double staining method immunofluorescence histochemical staining steps
If there are two antigens A and B that need to be displayed at the same time in the same specimen, the antibody of A antigen is labeled...
20
Oct
The price of untargeted metabolomic analysis
In many cases, non-targeted metabolomics analysis is required to better treat patients with diseases, and not all hospitals can do biom...
19
Oct
What is SWATH Mass Spectrometry?
SWATH (Sequential Windowed Acquisition of all Theoretical fragment ions) is a powerful mass spectrometry method designed fo...
18
Oct
The list of PEGylated drugs approved by FDA Up to 2024
Polyethylene glycol (PEG) is a polymer material that is widely used for covalent modification of biopolymers such as proteins and pepti...
18
Oct
Difference Between ELISPOT and ELISA
With the wide application of ELISA technology in the medical and biological fields, new breakthroughs have been made in the detection o...
17
Oct
ADC drug site-specific conjugation technology
As a new type of targeted anticancer drug, ADC has huge market prospects and development space. Although ADC drugs also have toxicity r...
14
Oct
What is Mass Spectrometry Multiple Reaction Monitoring (MRM) technology?
As an analytical method for mass spectrometry detection, multiple reaction monitoring (MRM) technology has the outstanding advantages o...
13
Oct
Application of MALDI-TOF
MALDI-TOF/TOF mass spectrometer is an analytical instrument used in the field of biology. The first step of mass spectrometry analysis ...
12
Oct
Introduction and Application of Liquid Chromatography-Mass Spectrometry(LC-MS)
Liquid Chromatograph Mass Spectrometer(LCMS) is an instrument that combines liquid chromatography and mass spectrometry. It combines th...
11
Oct
Introduction to Fluorescent Dyes for Flow Cytometry Applications
Fluorescence refers to the phenomenon of photoluminescence. When a certain room temperature substance is irradiated by incident light o...
10
Oct
Flow cytometer parameter measurement principle
Flow cytometer is a device for automatic analysis and sorting of cells. It can quickly measure, store and display a series of important...
09
Oct
Methods for the determination of plasma protein binding
Plasma Protein Binding (PPB) Overview
Plasma Protein Binding Rate (BRPP): This rate indicates how much of a drug binds...
07
Oct
The role of CYP450 in drug metabolism
Drugs entering the body will be catalyzed into polar molecules under the action of a series of enzymes, and the process of exerting dru...
05
Oct
The steps of immunofluorescence staining experiment
Immunofluorescence staining is a commonly used biochemical examination method, which is often used for the localization of antigens or ...
04
Oct
GCMS pyrolysis analysis and application
Gas-mass spectrometry (GC/MS) is widely used in the separation and identification of complex components, which has the high resolution ...
03
Oct
Chemical Properties and Applications of Fluorescent Probes
It has characteristic fluorescence in the ultraviolet-visible-near-infrared region, and its fluorescence properties (excitation and emi...
02
Oct
What are cyanine dyes?
Understanding Cyanine Dyes: Types, Structures, and Applications
What Are Cyanine Dyes?
Cyanine dyes are specialized color...
01
Oct
Reanalysis of test samples for macromolecular bioanalysis
The reliability of sample detection is one of the key points in the determination of biological sample concentration. There are many as...
30
Sep
What is polyethylene?
Overview
Polyethylene (PE) is a versatile thermoplastic resin made by polymerizing ethylene, often with small amounts of alpha-olefi...
29
Sep
What are lipids?
Lipids are a class of non-polar organic solvents that are insoluble in water but easily soluble in fatty solvents. and important organi...
28
Sep
What are phospholipids?
What Are Phospholipids?
Overview
what are phospholipids (phosphatides)Phospholipids were first identified in the huma...
27
Sep
One of the top company influencing Caco-2 Permeability Assay Market
Openpr: Workable Strategic Report on Caco-2 Permeability Assay Market – Some of the Top companies Influencing thi...
27
Sep
GLP-1 receptor agonist Drug list and mechanism of action
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of drugs commonly used for the treatment of type 2 diabetes and, more rec...
26
Sep
Precipitation Reaction: Ring Precipitation Reaction
Soluble antigen is mixed with the corresponding antibody. In the presence of electrolytes, if the ratio of the two is appropriate, a pr...
24
Sep
Alexa Fluor series fluorescent dyes and equivalents
Overview of Alexa Fluor Dyes
Alexa Fluor dyes, developed by American Molecular Probes, are popular fluorescent dyes for labe...
23
Sep
Classification and application of fluorescent dyes
Fluorescent dyes refer to substances that absorb light waves of a certain wavelength and emit light waves with a wavelength greater tha...
22
Sep
What is immunoturbidimetry?
Turbidimetric inhibition immunoassay is an analytical technique that combines liquid-phase precipitation with optical instrumen...
21
Sep
Principle and Analysis Method of Fluorescence Immunoassay (FIA)
Fluorescence immunoassay (FIA) has the advantages of high specificity of immune response and high sensitivity of fluorescence technolog...
20
Sep
Enzyme-linked immunosorbent assay (ELISA) classification methods and key points of operation
Enzyme-linked immunosorbent assay (ELISA or ELASA) refers to a qualitative and quantitative detection method that binds soluble antigen...
19
Sep
The Principle and Application of Chemiluminescence Immunoassay (CLIA) Technology
What is Chemiluminescence Immunoassay (CLIA)?
Introduced in 1977, Chemiluminescence Immunoassay (CLIA) revolutionized immunoassay te...
17
Sep
What are the methods of immunoassays?
Cytokines can be quantitatively or qualitatively detected by immunoassay technology by utilizing the specific binding properties of ant...
16
Sep
What is quantitative real-time PCR?
Quantitative Real-time PCR is a method of measuring the total amount of product after each polymerase chain reaction (PCR) cycle in a D...
15
Sep
Application and Analytical Technique of Immunoassay
Immunoassay is a method of detecting toxicants by using the toxicants and labeled toxicants to competitively bind antibodies. Can be us...
14
Sep
Methods for Pharmaceutical Analysis of Biological Samples
Pharmaceutical analysis methods for biological samples include chromatography, radionuclide labeling, immunological and microbiological...
13
Sep
What is the biotin-avidin system(BAS)
Biotin-Avidin-System (BAS) is a new biological reaction amplification system developed in the late 1970s. With the advent of various bi...
12
Sep
SELEX technology principle and characteristics
SELEX technology is the exponential enrichment of ligand system evolution technology (Systematic Evolution of Ligands by Exponential En...
09
Sep
What is the blood-brain barrier?
Blood-brain barrier: As early as 1885, it was found that after intravenous injection of aniline dye, the whole body tissues were staine...
08
Sep
Toxicokinetic model
Quantitative study of the time course of the absorption, distribution, biotransformation and excretion of chemical substances, called t...
07
Sep
Modern Toxicology and Research Methods
Modern toxicology is the study of various (chemical, physical, biological) harmful factors in human production and life practice from t...
06
Sep
Molecular Fluorescence Spectroscopy Analysis
Molecular fluorescence spectroscopic analysis is a method for qualitative or quantitative analysis of substances by utilizing the chara...
05
Sep
Toxicology study methods and advantages and disadvantages
Toxicological study is a term of radiation medicine and protection announced in 2014. study work to provide basic toxicological data fo...
03
Sep
What is toxicology?
Toxicology is an applied discipline that studies the harmful effects of exogenous factors (chemical, physical, biological factors) on b...
02
Sep
Infrared fluorescent protein
Infrared fluorescent proteins refer to a class of fluorescent proteins that emit infrared light. Because infrared light can easily pass...
01
Sep
Structure and function of green fluorescent protein
Green fluorescent protein (GFP) is a protein composed of about 238 amino acids, which can be excited from blue light to ultraviolet lig...
31
Aug
What is a bio-optical marker?
Bio-optical marker refers to marking biomolecules with markers with optical characteristics, so as to achieve the purpose of detection ...
30
Aug
Brief History and Status of Pharmacology
The improvement of people's living standard requires more and better new drugs. The development of pharmaceutical science provides the ...
29
Aug
The tasks and research content of pharmacology
Pharmacology is a science that studies the interaction law between drugs and the body and the mechanism of drug action, mainly includin...
27
Aug
What is toxicokinetics?
Toxicokinetics, referred to as toxicokinetics, is the application of the principles of pharmacokinetics in toxicology.
Apply mathematic...
23
Aug
What is titration analysis?
Titration is a means of quantitative analysis and a chemical experimental operation. It determines the content of a certain solute by t...
22
Aug
Gas Mass Spectrometry (GC-MS) Detection Features and Applications
Gas-mass spectrometry (GC/MS) is widely used in the separation and identification of complex components, which has the high resolution ...
20
Aug
What is autofluorescence?
Autofluorescence is the light naturally emitted by biological structures such as mitochondria and lysosomes when they absorb light, a...
19
Aug
Principle of time-of-flight mass spectrometry and ionization process
Time of Flight Mass Spectrometer is a very commonly used mass spectrometer.
The mass analyzer of this mass spectrometer is an ion drift...
18
Aug
Targeted and untargeted metabolomic analysis techniques
Metabolomics is the assembly of biochemical reactions in organisms, the material basis for life to maintain life, and an important basi...
17
Aug
Metabolomics analysis process
One: Metabolomics analysis process
Generally speaking, the metabolome analysis process is as follows: first, the metabolites are pre...
29
Jul
Amide coupling Protocol for Amino PEG
Does not require coupling agents. When PH value is 7-9, PEG amine can react with NHS ester effectively.
(1) Slowly dissolve amines...
29
Jul
Oligonucleotide applications and services
Oligonucleotides generally refer to linear polynucleotide fragments consisting of 2 to 10 nucleotide residues linked by phosphodiester ...
21
Jul
Introduction of APDye Fluors 647
APDye Fluor 647 is structurally similar to Alexa Fluor 647(AF647), and spectrally is almost identical to Cy5 Dye, Alexa Fluor 647, CF 6...
19
Apr
One prominent company operating in the CRO mass spectroscopy services market
Selbyville, Delaware , April 19, 2022 (GLOBE NEWSWIRE)
AxisPharm is...
07
Nov
Log D Measurement
Lipophilicity refers to the tendency of a compound to partition between a lipophilic organic phase and a pol...
28
Aug
Stem cells successfully repair refractory type 1 diabetes
With the improvement of people's living standard, the incidence of diabetes is increasing day by day. This poses ...
27
Aug
ADC drug for urothelial carcinoma( effective rate 81.6%)
Urothelial carcinoma (UC) is a common type of bladder cancer, accounting for approximately 90% of all bladder can...
18
Aug
Can changing your diet help fight cancer?
An article published on «Nature» stated that diet can adjust insulin levels and improve the anticancer effect of ...
14
Aug
Can proteomic technology be used for cancer clinical research?
Analysis of the tumor gene portfolio transcriptome is now a tool for novel biomarkers, but changes in proteome ex...
13
Aug
Scientists Develop Magical Nanoparticles For Treat The Brain Cancer
In recent years, due to the development of medical technology, scientists continue to explore new ways to treat c...
05
Aug
Focus on exosome applications and challenges
Currently, the main application directions of exosomes include as drug delivery carriers; Immune activation and i...
31
Jul
Omics applications of biomarkers (proteomics/metabolomics)
The biomarker is a kind of characteristic biochemical index that can be evaluated objectively, and the biologica...
30
Jul
Proteomic Technology – Tumor Marker “Radar”
Proteomics can analyze and identify the changes of protein molecules in tumor cells, providing valuable informati...
24
Jul
Cancer Driver Genes Affect Cell Surface Proteins And Glycoprotein Groups
The cell surface proteome is the interface where normal cells and cancer cells contact the extracellular space an...
22
Jul
How Structure and Ligand-Based Drug Design Shape Modern Drug Discovery
In modern drug discovery, two main approaches are widely used: Structure-Based Drug Design (SBDD) and Ligand-Bas...
16
Jul
Methodology of Quantitative Proteomics
The study of life phenomena and laws from the perspective of the direct executor of life activities—proteins, especially disease preven...
13
Jul
What is metabolomics?
The metabolome is downstream of the gene regulatory network and protein action network and provides terminal info...
10
Jul
How to use proteomics technology for cancer clinical research?
The analysis of tumor genome and transcriptome has now become a tool for discovering new biomarkers, but changes...
08
Jul
What are the most important things to pay attention to during the preparation of antibody-conjugated drugs?
Antibody conjugated drugs are formed by linking monoclonal antibodies targeting specific antigens and small molec...
03
Jul
Proteomics Study The Molecular Mechanism Of Unraveling The Depolymerization And Ubiquitylation Of Stress Particles
When the cell responds to stress, it will stop the translation process and selectively turn on the expression of ...
30
Jun
New type of cancer immunotherapy: only kills cancer cells, not healthy cells accidentally
In 2018, two pioneers in cancer immunotherapy won the Nobel Prize in Physiology or Medicine. This newly pioneered...
26
Jun
ADC Linkers And Research Progress In Detail
ADC linkers are not only the molecular parts that form covalent connections between antibodies and small molecula...
23
Jun
Key Points To Realize The Anti-cancer Potential Of ADC Drugs
The past decade has been a decade of accumulation and harvest for ADC. After the second new ADC drug Adcetris (Br...
18
Jun
The use of fluorescent dyes and how to judge the brightness?
Fluorescent dyes refer to substances that absorb light waves of a certain wavelength and emit light waves of anot...
09
Jun
Esophageal cancer activates the ancient virus hidden in the human genome and also provides new targets for cancer treatment
According to the latest global cancer burden data released by the International Agency for Research on Cancer of ...
09
Jun
Harvard University Academician Mitragotri: Pointing out the direction for drug delivery research
Drug delivery system refers to a technical system that comprehensively regulates the distribution of drugs in org...
09
Jun
Acellular Extracellular Matrix Bio-ink Build Tissue And Organ-Specific Microenvironment
Tissue engineering is a revolutionary strategy to rebuild new organs or tissues through the use of various biomed...
09
Jun
Protective agent in freeze-drying
Freeze-drying is a drying method in which the drug solution that needs to be dried is frozen into a solid in adva...
09
Jun
PEG solution therapy in treating acute hepatic encephalopathy
Scientists from Baylor University Medical Center pointed out, the common drugs used to clean the patient’s intest...
09
Jun
ADCs Enfortumab Vedotin Receives Accelerated FDA Approval
Urothelial cancer accounts for more than 90% of bladder cancer. Patients diagnosed with metastatic disease have a...
09
Jun
Dendrimer targeted therapy for cancer
In view of the local invasiveness and remote metastasis characteristics of malignant tumors, the treatment effec...
09
Jun
Cell therapy of vitamin-lipid nanoparticles to treat sepsis
Sepsis is an organ dysfunction caused by the host's abnormal immune response to infection. Sepsis affects millions of people worldwid...
09
Jun
New drug for multiple sclerosis! FDA approval of PLEGRIDY (peginterferon beta-1a)
Biogen recently announced that the U.S. Food and Drug Administration (FDA) has approved Plegridy (pegylated inte...
09
Jun
Folate receptor crystal structure-anti-cancer drug development
Folic acid and vitamin B9 is an essential substance for cell growth. Indiana University scientists have revealed...
09
Jun
Cleavable & Non- Cleavable Linkers with Antibody-Drug Conjugates
Antibody-drug conjugates (ADC) have been identified as the main treatment therapy for clinical cancer treatment. The principle of ADC i...
09
Jun
The Rise Of 3D Cell Printing Technology
What if scientists no longer rely on scarce organ donations, but can build healthy new organs quickly and cheapl...
09
Jun
PEG Polypeptides Chemical Modification
A polypeptide is a compound formed by multiple amino acids connected by peptide bonds. They are ubiquitous in org...
09
Jun
Types of anti-tumor prodrugs that exist
Prodrugs is a compound through enzyme or nonenzymatic action in the body to release active matter. It has less ac...
09
Jun
Maleimide | Azide | Alkynes | Carboxylic acid | Succinimidy l Ester Reactive Dyes
Fluorescent fuel is also called fluorescent probe. She has the advantages of fast detection speed, good reproducibility, less sample vo...
09
Jun
Have you used these common labeling tools?
The antibody or protein labeling refers to covalently linking a target substance (enzyme, fluorescein, biotin) to an antibody or ot...
08
Jun
FDA Approves Biogen’s New Alzheimer’s Drug Aducanumab
On June 7, the US FDA announced the approval of Biogen/Eisai's Aβ (amyloid β) antibody Aduhelm (aducanumab) for t...
29
May
Monoclonal Antibody-drug Stability Optimization
Monoclonal Antibody-Drug Stability Optimization
Monoclonal antibody drugs are essential in biopharmaceuticals, ...
26
May
Photoimmune ADC: A New Frontier in Targeted Cancer Therapy
Photoimmune ADCs represent an innovative type of antibody-drug conjugate (ADC) that combines targeted antibodi...
20
May
New Cancer Materials, Nano-Gold Cancer Treatments
The history of human struggle with cancer is very long, from surgery, radiotherapy, and chemotherapy, to immunot...
06
May
Unlocking the Future: How GPCR-Targeted ADCs Are Changing Cancer Therapy
G protein-coupled receptors (GPCRs) are crucial membrane proteins involved in cellular signaling and various dise...
29
Apr
Azide/Alkynyl Modified Click Chemistry Reagent
Click chemistry this concept was originally derived from the observation of natural products and biosynthetic pa...
24
Apr
Growth factor PEG-fibronectin hydrogel
Extracellular matrix-derived matrigel contains a variety of growth factors. And it has ECM properties that suppor...
16
Apr
Knowledge for Ion Chromatography–HPIC
Since the birth of Ion Chromatography in 1975 more than 40-year rapid development, ion chromatography has gradua...
14
Apr
Tisotumab vedotin, a new drug for cervical cancer ADC will apply for marketing!
Cervical cancer originates from the cells of the cervix. The disease is still one of the leading causes of cancer...
06
Apr
HER2, the first ADC drug for HER2-positive gastric cancer, approved in Japan
Abstract
Daiichi Sankyo recently announced that Japan’s Ministry of Hea...
29
Mar
What is a fluorescent probe?
Fluorescence is a luminescence phenomenon of photoluminescence. When certain substances are excited by light, ele...
25
Mar
What is the click chemistry?
Click chemistry is a series of reactions proposed by K. Barry Sharpless, the winner of the Nobel Prize in Chemis...
22
Mar
Polyethylene Glycol Modification Reagent in Protein Medicine
Modified PEG is also called modified polyethylene glycol, which is a PEG-modified by a chemical modification grou...
16
Mar
What is cancer? How should we prevent it?
Cancer refers to malignant tumors originating from epithelial tissues and is the most common type of malignant t...
12
Mar
What is ADC(Antibody-drug Conjugates)?
Abstract
ADCs combine the high specificity of monoclonal a...
10
Mar
What is PEG/PEG-linker？
Polyethylene glycol(PEG) is an ethylene glycol polymer with a relative molecular weight of 200 to 8000 or more t...
14
Sep
AxisPharm: A Leading Name in Proteome Profiling
AxisPharm is proud to be recognized as one of the top 85 proteomics service providers in the industry. We leverag...
31
May
AxisPharm acquired HT-Labs to expand its presence in analytical services
05-31-2018, San Diego, CA
AxisPharm acquired HT-Labs, a well establ...