What Is Ionizable Lipids?
Ionizable lipids are a category of lipid molecules that maintain a neutral charge at normal physiological pH but ...
25
Sep
PEG & ADC
25
Sep
What are Cationic Lipids?
Cationic lipids belong to a group of lipid molecules characterized by a permanently positively charged head group...
02
Jul
Agilent 1290 Infinity UPLC/ AB Sciex 5500 Qtrap Mass Spectrometer
The 1290 Infinity...
28
Jun
Polyethylene Glycol Classification
Polyethylene Glycol can be categorized into different types based on factors such as synthesis geometry, molecul...
20
Jun
Solid Lipid Nanoparticles (SLNs)
Solid lipid nanoparticles (SLNs) have emerged as a promising drug delivery system due to their various advantage...
19
Jun
In Vitro vs In Vivo Studies of Polyethylene Glycol (PEG) Linkers
Polyethylene glycol (PEG) molecules have been used extensively as linkers in drug development, mainly due to the...
22
May
Why Human epidermal growth factor receptor 2 (HER2) is an attractive target for ADC
HER2 (Human Epidermal Growth Factor Receptor 2) is a protein that ...
10
Feb
What is the difference between ADC linker and PEG linker?
Linkers are molecules used to connect two different molecules together to form a larger, more complex structure. They are used in many ...
09
Feb
Application of PEG Linker
A PEG (polyethylene glycol) linker is a chemical compound that is used to connect two or more molecules together. PEG is a water-solubl...
24
Nov
Antibody-drug conjugates(ADCs) list Approved by FDA(2000-2023)
Antibody-drug conjugates(ADCs) are use specific linkers to connect antibodies and small molecule cytotoxic drugs, and their main compon...
14
Nov
What is biotinylation?
Biotinylation refers to the process of covalently attaching biotin to proteins, nucleic acids or other molecules. Due to the small mole...
11
Nov
What are the ingredients of a COVID-19 vaccine?
What is an mRNA vaccine? Like other types of vaccines, mRNA vaccines work by activating our own immune response, so that our bodies pro...
10
Nov
The Importance of Polyethylene Glycol (PEG) to the Pharmaceutical Industry
Polyethylene glycol (PEG) is a safe, inactive, and nontoxic polymer that is commonly used for molecular modification. Therapeutic benef...
09
Nov
Technical characteristics of PROTAC technology in drug research and development
Most of the drugs currently in clinical use are based on small molecules and use an "occupancy-driven" mode of action to inhibit the fu...
08
Nov
What is SPDP Crosslinker?
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive grou...
07
Nov
What is SPAAC?
The 2022 Nobel Prize in Chemistry has been awarded to American chemist Carolyn Bertozzi, Danish chemist Morten Meldal and American chem...
05
Nov
Difference Between Polymer PEG (Polydisperse PEG) and Monodisperse PEG
The polymer PEG is a polyethylene glycol (PEG) polymer, a polyether compound derived from petroleum that has many applications ranging ...
04
Nov
What is polyethylene glycol (PEG) modification?
Polyethylene glycol (PEG) modification is a polyethylene glycol with functional groups, which is mainly used for protein drug modificat...
28
Oct
What are ADC Linkers?
Antibody-drug conjugates (ADCs) are the most popular chemoimmunotherapy agents in recent years. ADCs can enhance the ability to target ...
18
Oct
The list of PEGylated drugs approved by FDA Up to 2022
Polyethylene glycol (PEG) is a polymer material that is widely used for covalent modification of biopolymers such as proteins and pepti...
07
Oct
The role of CYP450 in drug metabolism
Drugs entering the body will be catalyzed into polar molecules under the action of a series of enzymes, and the process of exerting dru...
30
Sep
What is polyethylene?
Polyethylene (PE) is a thermoplastic resin obtained by polymerizing ethylene. In industry, copolymers of ethylene with small amounts of...
29
Sep
What are lipids?
Lipids are a class of non-polar organic solvents that are insoluble in water but easily soluble in fatty solvents. and important organi...
28
Sep
What are phospholipids?
Phospholipids are lipids containing phosphoric acid and belong to complex lipids. Phospholipids are the main components of biological m...
27
Sep
GLP-1 receptor agonist Drug list and mechanism of action
Glucagon-like peptide-1 receptor agonists, namely GLP-1 receptor agonists, are a class of drugs for the treatment of type 2 diabetes. T...
08
Jul
What is the fluorescent dye?
Fluorescent dyes refer to substances that absorb a light wave of a certain wavelength and emit another light wave with a wavelength gre...
07
Nov
Log D Measurement
Lipophilicity refers to the tendency of a compound to partition between a lipophilic organic phase and a pol...
28
Aug
Stem cells successfully repair refractory type 1 diabetes
With the improvement of people's living standard, the incidence of diabetes is increasing day by day. This poses ...
27
Aug
ADC drug for urothelial carcinoma( effective rate 81.6%)
Urothelial carcinoma (UC) is a common type of bladder cancer, accounting for approximately 90% of all bladder can...
18
Aug
Can changing your diet help fight cancer?
An article published on «Nature» stated that diet can adjust insulin levels and improve the anticancer effect of ...
14
Aug
Can proteomic technology be used for cancer clinical research?
Analysis of the tumor gene portfolio transcriptome is now a tool for novel biomarkers, but changes in proteome ex...
13
Aug
Scientists Develop Magical Nanoparticles For Treat The Brain Cancer
In recent years, due to the development of medical technology, scientists continue to explore new ways to treat c...
07
Aug
Application of lipidomics in the diagnosis and treatment of tumors
Lipids have a number of key biological functions in cancer. There are characteristic changes in lipid metabolism ...
05
Aug
Focus on exosome applications and challenges
Currently, the main application directions of exosomes include as drug delivery carriers; Immune activation and i...
31
Jul
Omics applications of biomarkers (proteomics/metabolomics)
The biomarker is a kind of characteristic biochemical index that can be evaluated objectively, and the biological...
30
Jul
Proteomic Technology – Tumor Marker “Radar”
Proteomics can analyze and identify the changes of protein molecules in tumor cells, providing valuable informati...
24
Jul
Cancer Driver Genes Affect Cell Surface Proteins And Glycoprotein Groups
The cell surface proteome is the interface where normal cells and cancer cells contact the extracellular space an...
22
Jul
Drug Development: Virtual Screening/Molecular Docking/QSAR
Structure-based drug design (SBDD) and ligand-based drug design (LBDD) are two basic methods of computer-aided dr...
13
Jul
What is metabolomics?
The metabolome is downstream of the gene regulatory network and protein action network and provides terminal info...
10
Jul
How to use proteomics technology for cancer clinical research?
The analysis of tumor genome and transcriptome has now become a tool for discovering new biomarkers, but changes ...
08
Jul
What are the most important things to pay attention to during the preparation of antibody-conjugated drugs?
Antibody conjugated drugs are formed by linking monoclonal antibodies targeting specific antigens and small molec...
03
Jul
Proteomics Study The Molecular Mechanism Of Unraveling The Depolymerization And Ubiquitylation Of Stress Particles
When the cell responds to stress, it will stop the translation process and selectively turn on the expression of ...
30
Jun
New type of cancer immunotherapy: only kills cancer cells, not healthy cells accidentally
In 2018, two pioneers in cancer immunotherapy won the Nobel Prize in Physiology or Medicine. This newly pioneered...
26
Jun
ADC Linkers And Research Progress In Detail
Linkers are not only the molecular parts that form covalent connections between antibodies and small molecular pa...
23
Jun
Key Points To Realize The Anti-cancer Potential Of ADC Drugs
The past decade has been a decade of accumulation and harvest for ADC. After the second new ADC drug Adcetris (Br...
18
Jun
The use of fluorescent dyes and how to judge the brightness?
Fluorescent dyes refer to substances that absorb light waves of a certain wavelength and emit light waves of anot...
09
Jun
Esophageal cancer activates the ancient virus hidden in the human genome and also provides new targets for cancer treatment
According to the latest global cancer burden data released by the International Agency for Research on Cancer of ...
09
Jun
Harvard University Academician Mitragotri: Pointing out the direction for drug delivery research
Drug delivery system refers to a technical system that comprehensively regulates the distribution of drugs in org...
09
Jun
Protein Separation And Purification
At the end of the research, it depends on the expression product of the group. Whether it is used for detection o...
09
Jun
Acellular Extracellular Matrix Bio-ink Build Tissue And Organ-Specific Microenvironment
Tissue engineering is a revolutionary strategy to rebuild new organs or tissues through the use of various biomed...
09
Jun
Protective agent in freeze-drying
Freeze-drying is a drying method in which the drug solution that needs to be dried is frozen into a solid in adva...
09
Jun
PEG solution therapy in treating acute hepatic encephalopathy
Scientists from Baylor University Medical Center pointed out, the common drugs used to clean the patient’s intest...
09
Jun
ADCs Enfortumab Vedotin Receives Accelerated FDA Approval
Urothelial cancer accounts for more than 90% of bladder cancer. Patients diagnosed with metastatic disease have a...
09
Jun
Dendrimer targeted therapy for cancer
In view of the local invasiveness and remote metastasis characteristics of malignant tumors, the treatment effec...
09
Jun
Cell therapy of vitamin-lipid nanoparticles to treat sepsis
Sepsis is an organ dysfunction caused by the host's abnormal immune response to infection. Sepsis affects millions of people worldwid...
09
Jun
New drug for multiple sclerosis! FDA approval of PLEGRIDY (peginterferon beta-1a)
Biogen recently announced that the U.S. Food and Drug Administration (FDA) has approved Plegridy (pegylated inte...
09
Jun
Folate receptor crystal structure-anti-cancer drug development
Folic acid and vitamin B9 is an essential substance for cell growth. Indiana University scientists have revealed...
09
Jun
Cleavable & Non- Cleavable Linkers with Antibody-Drug Conjugates
Antibody-drug conjugates (ADC) have been identified as the main treatment therapy for clinical cancer treatment. The principle of ADC i...
09
Jun
The Rise Of 3D Cell Printing Technology
What if scientists no longer rely on scarce organ donations, but can build healthy new organs quickly and cheapl...
09
Jun
PEG Polypeptides Chemical Modification
A polypeptide is a compound formed by multiple amino acids connected by peptide bonds. They are ubiquitous in org...
09
Jun
Types of anti-tumor prodrugs that exist
Prodrugs is a compound through enzyme or nonenzymatic action in the body to release active matter. It has less ac...
09
Jun
Have you used these common labeling tools?
The antibody or protein labeling refers to covalently linking a target substance (enzyme, fluorescein, biotin) to an antibody or ot...
08
Jun
FDA Approves Biogen’s New Alzheimer’s Drug Aducanumab
On June 7, the US FDA announced the approval of Biogen/Eisai's Aβ (amyloid β) antibody Aduhelm (aducanumab) for t...
29
May
Monoclonal Antibody-drug Stability Optimization
Monoclonal antibody drugs are an important branch of biopharmaceuticals, which have received widespread attention...
26
May
Can global ADC drugs-photoimmunotherapy highlight the encirclement?
In recent years, antibody-drug conjugates (ADCs) have been widely sought after for their excellent clinical perfo...
20
May
New Cancer Materials, Nano-Gold Cancer Treatments
The history of human struggle with cancer is very long, from surgery, radiotherapy, and chemotherapy, to immunot...
06
May
Development trend of G protein-coupled receptor ADC drugs
G Protein-Coupled Receptors (GPCR) are a large family of seven types of transmembrane domain proteins expressed o...
29
Apr
Azide/Alkynyl Modified Click Chemistry Reagent
Click chemistry this concept was originally derived from the observation of natural products and biosynthetic pa...
24
Apr
Growth factor PEG-fibronectin hydrogel
Extracellular matrix-derived matrigel contains a variety of growth factors. And it has ECM properties that suppor...
16
Apr
Knowledge for Ion Chromatography–HPIC
Since the birth of Ion Chromatography in 1975 more than 40-year rapid development, ion chromatography has gradual...
14
Apr
Tisotumab vedotin, a new drug for cervical cancer ADC will apply for marketing!
Cervical cancer originates from the cells of the cervix. The disease is still one of the leading causes of cancer...
10
Apr
Glutamine metabolism and cancer treatment
In 1935, Hans Krebs proposed the famous tricarboxylic acid cycle (TCA), pointing out the importance of glutamine ...
06
Apr
HER2, the first ADC drug for HER2-positive gastric cancer, approved in Japan
Abstract
Daiichi Sankyo recently announced that Japan’s Ministry of Hea...
29
Mar
What is a fluorescent probe?
Fluorescence is a luminescence phenomenon of photoluminescence. When certain substances are excited by light, ele...
25
Mar
What is the click chemistry?
Click chemistry is a series of reactions proposed by K. Barry Sharpless, the winner of the Nobel Prize in Chemis...
22
Mar
Polyethylene Glycol Modification Reagent in Protein Medicine
Modified PEG is also called modified polyethylene glycol, which is a PEG-modified by a chemical modification grou...
16
Mar
What is cancer? How should we prevent it?
Cancer refers to malignant tumors originating from epithelial tissues and is the most common type of malignant t...
12
Mar
What is ADC(Antibody-drug Conjugates)?
Abstract
ADCs combine the high specificity of monoclonal a...
10
Mar
What is PEG/PEG-linker？
Polyethylene glycol(PEG) is an ethylene glycol polymer with a relative molecular weight of 200 to 8000 or more t...