PEG & ADC Archives

24 Nov

Antibody-drug conjugates(ADCs) list Approved by FDA(2000-2022)

November 25, 2022
By axispharm

Antibody-drug conjugates(ADCs) are use specific linkers to connect antibodies and small molecule cytotoxic drugs, and their main compon...

14 Nov

PEG & ADC

What is biotinylation?

November 15, 2022
By axispharm

Biotinylation refers to the process of covalently attaching biotin to proteins, nucleic acids or other molecules. Due to the small mole...

11 Nov

PEG & ADC

What are the ingredients of a COVID-19 vaccine?

November 11, 2022
By axispharm

What is an mRNA vaccine? Like other types of vaccines, mRNA vaccines work by activating our own immune response, so that our bodies pro...

10 Nov

PEG & ADC

The Importance of Polyethylene Glycol (PEG) to the Pharmaceutical Industry

November 11, 2022
By axispharm

Polyethylene glycol (PEG) is a safe, inactive, and nontoxic polymer that is commonly used for molecular modification. Therapeutic benef...

09 Nov

PEG & ADC

Technical characteristics of PROTAC technology in drug research and development

November 9, 2022
By coolking deng

Most of the drugs currently in clinical use are based on small molecules and use an "occupancy-driven" mode of action to inhibit the fu...

08 Nov

PEG & ADC

What is SPDP Crosslinker?

November 8, 2022
By axispharm

SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive grou...

07 Nov

PEG & ADC

What is SPAAC?

November 7, 2022
By axispharm

The 2022 Nobel Prize in Chemistry has been awarded to American chemist Carolyn Bertozzi, Danish chemist Morten Meldal and American chem...

05 Nov

PEG & ADC

Difference Between Polymer PEG (Polydisperse PEG) and Monodisperse PEG

November 5, 2022
By axispharm

The polymer PEG is a polyethylene glycol (PEG) polymer, a polyether compound derived from petroleum that has many applications ranging ...

04 Nov

PEG & ADC

What is polyethylene glycol (PEG) modification?

November 4, 2022
By axispharm

Polyethylene glycol (PEG) modification is a polyethylene glycol with functional groups, which is mainly used for protein drug modificat...

28 Oct

PEG & ADC

What are ADC Linkers?

October 29, 2022
By axispharm

Antibody-drug conjugates (ADCs) are the most popular chemoimmunotherapy agents in recent years. ADCs can enhance the ability to target ...

18 Oct

PEG & ADC

The list of PEGylated drugs approved by FDA Up to 2022

October 18, 2022
By axispharm

Polyethylene glycol (PEG) is a polymer material that is widely used for covalent modification of biopolymers such as proteins and pepti...

07 Oct

PEG & ADC

The role of CYP450 in drug metabolism

October 7, 2022
By axispharm

Drugs entering the body will be catalyzed into polar molecules under the action of a series of enzymes, and the process of exerting dru...

30 Sep

PEG & ADC

What is polyethylene?

September 30, 2022
By axispharm

Polyethylene (PE) is a thermoplastic resin obtained by polymerizing ethylene. In industry, copolymers of ethylene with small amounts of...

29 Sep

PEG & ADC

What are lipids?

September 29, 2022
By axispharm

Lipids are a class of non-polar organic solvents that are insoluble in water but easily soluble in fatty solvents. and important organi...

28 Sep

PEG & ADC

What are phospholipids?

September 28, 2022
By axispharm

Phospholipids are lipids containing phosphoric acid and belong to complex lipids. Phospholipids are the main components of biological m...

27 Sep

PEG & ADC

GLP-1 receptor agonist Drug list and mechanism of action

September 27, 2022
By axispharm

Glucagon-like peptide-1 receptor agonists, namely GLP-1 receptor agonists, are a class of drugs for the treatment of type 2 diabetes. T...

08 Jul

PEG & ADC

What is the fluorescent dye?

July 8, 2022
By axispharm

Fluorescent dyes refer to substances that absorb a light wave of a certain wavelength and emit another light wave with a wavelength gre...

07 Nov

PEG & ADC

Log D Measurement

November 7, 2021
By admin

Lipophilicity refers to the tendency of a compound to partition between a lipophilic organic phase and a pol...

28 Aug

PEG & ADC

Stem cells successfully repair refractory type 1 diabetes

August 28, 2021
By axispharm

With the improvement of people's living standard, the incidence of diabetes is increasing day by day. This poses ...

27 Aug

PEG & ADC

ADC drug for urothelial carcinoma( effective rate 81.6%)

June 28, 2022
By axispharm

Urothelial carcinoma (UC) is a common type of bladder cancer, accounting for approximately 90% of all bladder can...

18 Aug

PEG & ADC

Can changing your diet help fight cancer?

August 18, 2021
By axispharm

An article published on «Nature» stated that diet can adjust insulin levels and improve the anticancer effect of ...

14 Aug

PEG & ADC

Can proteomic technology be used for cancer clinical research?

August 14, 2021
By axispharm

Analysis of the tumor gene portfolio transcriptome is now a tool for novel biomarkers, but changes in proteome ex...

13 Aug

PEG & ADC

Scientists Develop Magical Nanoparticles For Treat The Brain Cancer

August 13, 2021
By axispharm

In recent years, due to the development of medical technology, scientists continue to explore new ways to treat c...

07 Aug

PEG & ADC

Application of lipidomics in the diagnosis and treatment of tumors

August 7, 2021
By axispharm

Lipids have a number of key biological functions in cancer. There are characteristic changes in lipid metabolism ...

05 Aug

PEG & ADC

Focus on exosome applications and challenges

August 5, 2021
By axispharm

Currently, the main application directions of exosomes include as drug delivery carriers; Immune activation and i...

31 Jul

PEG & ADC

Omics applications of biomarkers (proteomics/metabolomics)

July 31, 2021
By axispharm

The biomarker is a kind of characteristic biochemical index that can be evaluated objectively, and the biological...

30 Jul

PEG & ADC

Proteomic Technology – Tumor Marker “Radar”

July 30, 2021
By axispharm

Proteomics can analyze and identify the changes of protein molecules in tumor cells, providing valuable informati...

24 Jul

PEG & ADC

Cancer Driver Genes Affect Cell Surface Proteins And Glycoprotein Groups

July 24, 2021
By axispharm

The cell surface proteome is the interface where normal cells and cancer cells contact the extracellular space an...

22 Jul

PEG & ADC

Drug Development: Virtual Screening/Molecular Docking/QSAR

July 22, 2021
By axispharm

Structure-based drug design (SBDD) and ligand-based drug design (LBDD) are two basic methods of computer-aided dr...

16 Jul

PEG & ADC

Methodology of Quantitative Proteomics

July 16, 2021
By axispharm

The study of life phenomena and laws from the perspective of the direct executor of life activities—proteins, esp...

13 Jul

PEG & ADC

What is metabolomics?

July 13, 2021
By axispharm

The metabolome is downstream of the gene regulatory network and protein action network and provides terminal info...

10 Jul

PEG & ADC

How to use proteomics technology for cancer clinical research?

July 10, 2021
By axispharm

The analysis of tumor genome and transcriptome has now become a tool for discovering new biomarkers, but changes ...

08 Jul

PEG & ADC

What are the most important things to pay attention to during the preparation of antibody-conjugated drugs?

July 8, 2021
By axispharm

Antibody conjugated drugs are formed by linking monoclonal antibodies targeting specific antigens and small molec...

03 Jul

PEG & ADC

Proteomics Study The Molecular Mechanism Of Unraveling The Depolymerization And Ubiquitylation Of Stress Particles

July 3, 2021
By axispharm

When the cell responds to stress, it will stop the translation process and selectively turn on the expression of ...

30 Jun

PEG & ADC

New type of cancer immunotherapy: only kills cancer cells, not healthy cells accidentally

June 30, 2021
By axispharm

In 2018, two pioneers in cancer immunotherapy won the Nobel Prize in Physiology or Medicine. This newly pioneered...

26 Jun

PEG & ADC

ADC Linkers And Research Progress In Detail

June 26, 2021
By axispharm

Linkers are not only the molecular parts that form covalent connections between antibodies and small molecular pa...

23 Jun

PEG & ADC

Key Points To Realize The Anti-cancer Potential Of ADC Drugs

June 23, 2021
By axispharm

The past decade has been a decade of accumulation and harvest for ADC. After the second new ADC drug Adcetris (Br...

18 Jun

PEG & ADC

The use of fluorescent dyes and how to judge the brightness?

June 18, 2021
By axispharm

Fluorescent dyes refer to substances that absorb light waves of a certain wavelength and emit light waves of anot...

09 Jun

PEG & ADC

Esophageal cancer activates the ancient virus hidden in the human genome and also provides new targets for cancer treatment

June 9, 2021
By axispharm

According to the latest global cancer burden data released by the International Agency for Research on Cancer of ...

09 Jun

PEG & ADC

Harvard University Academician Mitragotri: Pointing out the direction for drug delivery research

June 9, 2021
By axispharm

Drug delivery system refers to a technical system that comprehensively regulates the distribution of drugs in org...

09 Jun

PEG & ADC

Protein Separation And Purification

June 9, 2021
By axispharm

At the end of the research, it depends on the expression product of the group. Whether it is used for detection o...

09 Jun

PEG & ADC

Indian Long Pepper Extract Anti-glioblastoma Drug

June 9, 2021
By axispharm

09 Jun

PEG & ADC

Acellular Extracellular Matrix Bio-ink Build Tissue And Organ-Specific Microenvironment

June 9, 2021
By axispharm

Tissue engineering is a revolutionary strategy to rebuild new organs or tissues through the use of various biomed...

09 Jun

PEG & ADC

Protective agent in freeze-drying

June 9, 2021
By axispharm

Freeze-drying is a drying method in which the drug solution that needs to be dried is frozen into a solid in adva...

09 Jun

PEG & ADC

PEG solution therapy in treating acute hepatic encephalopathy

June 9, 2021
By axispharm

Scientists from Baylor University Medical Center pointed out, the common drugs used to clean the patient’s intest...

09 Jun

PEG & ADC

ADCs Enfortumab Vedotin Receives Accelerated FDA Approval

June 9, 2021
By axispharm

Urothelial cancer accounts for more than 90% of bladder cancer. Patients diagnosed with metastatic disease have a...

09 Jun

PEG & ADC

Dendrimer targeted therapy for cancer

July 14, 2022
By axispharm

In view of the local invasiveness and remote metastasis characteristics of malignant tumors, the treatment effec...

09 Jun

PEG & ADC

Cell therapy of vitamin-lipid nanoparticles to treat sepsis

June 9, 2021
By axispharm

Sepsis is an organ dysfunction caused by the host's abnormal immune response to infection. Sepsis affects million...

09 Jun

PEG & ADC

New drug for multiple sclerosis! FDA approval of PLEGRIDY (peginterferon beta-1a)

August 31, 2022
By axispharm

Biogen recently announced that the U.S. Food and Drug Administration (FDA) has approved Plegridy (pegylated inte...

09 Jun

PEG & ADC

Folate receptor crystal structure-anti-cancer drug development

August 31, 2022
By axispharm

Folic acid and vitamin B9 is an essential substance for cell growth. Indiana University scientists have revealed...

09 Jun

PEG & ADC

Cleavable& Non- Cleavable Linkers with Antibody-Drug Conjugates

June 9, 2021
By axispharm

Antibody-drug conjugates (ADC) have been identified as the main treatment therapy for clinical cancer treatment. ...

09 Jun

PEG & ADC

The Rise Of 3D Cell Printing Technology

August 31, 2022
By axispharm

What if scientists no longer rely on scarce organ donations, but can build healthy new organs quickly and cheapl...

09 Jun

PEG & ADC

PEG Polypeptides Chemical Modification

June 9, 2021
By axispharm

A polypeptide is a compound formed by multiple amino acids connected by peptide bonds. They are ubiquitous in org...

09 Jun

PEG & ADC

Types of anti-tumor prodrugs that exist

June 9, 2021
By axispharm

Prodrugs is a compound through enzyme or nonenzymatic action in the body to release active matter. It has less ac...

09 Jun

PEG & ADC

Maleimide|Azide|Alkynes|Carboxylic acid|Succinimidyl Ester Reactive Dyes

June 9, 2021
By axispharm

Fluorescent fuel is also called fluorescent probe. She has the advantages of fast detection speed, good reproduci...

09 Jun

PEG & ADC

Have you used these common marking tools?

June 9, 2021
By axispharm

The antibody or protein labeling refers to covalently linking a target substance (enzyme, fluorescein, biotin) to...

08 Jun

PEG & ADC

FDA Approves Biogen’s New Alzheimer’s Drug Aducanumab

June 8, 2021
By axispharm

On June 7, the US FDA announced the approval of Biogen/Eisai's Aβ (amyloid β) antibody Aduhelm (aducanumab) for t...

29 May

PEG & ADC

Monoclonal Antibody-drug Stability Optimization

June 4, 2021
By axispharm

Monoclonal antibody drugs are an important branch of biopharmaceuticals, which have received widespread attention...

26 May

PEG & ADC

Can global ADC drugs-photoimmunotherapy highlight the encirclement?

June 9, 2021
By axispharm

In recent years, antibody-drug conjugates (ADCs) have been widely sought after for their excellent clinical perfo...

20 May

PEG & ADC

New Cancer Materials, Nano-Gold Cancer Treatments

August 31, 2022
By axispharm

The history of human struggle with cancer is very long, from surgery, radiotherapy, and chemotherapy, to immunot...

06 May

PEG & ADC

Development trend of G protein-coupled receptor ADC drugs

June 9, 2021
By axispharm

G Protein-Coupled Receptors (GPCR) are a large family of seven types of transmembrane domain proteins expressed o...

29 Apr

PEG & ADC

Azide/Alkynyl Modified Click Chemistry Reagent

June 9, 2021
By axispharm

Click chemistry (Click chemistry), this concept was originally derived from the observation of natural products a...

24 Apr

PEG & ADC

Growth factor PEG-fibronectin hydrogel

June 9, 2021
By axispharm

Extracellular matrix-derived matrigel contains a variety of growth factors. And it has ECM properties that suppor...

16 Apr

PEG & ADC

Knowledge for Ion Chromatography–HPIC

June 9, 2021
By axispharm

Since the birth of Ion Chromatography in 1975 more than 40-year rapid development, ion chromatography has gradual...

14 Apr

PEG & ADC

Tisotumab vedotin, a new drug for cervical cancer ADC will apply for marketing!

June 9, 2021
By axispharm

Cervical cancer originates from the cells of the cervix. The disease is still one of the leading causes of cancer...

10 Apr

PEG & ADC

Glutamine metabolism and cancer treatment

June 9, 2021
By axispharm

In 1935, Hans Krebs proposed the famous tricarboxylic acid cycle (TCA), pointing out the importance of glutamine ...

06 Apr

PEG & ADC

HER2, the first ADC drug for HER2-positive gastric cancer, approved in Japan

June 9, 2021
By axispharm

Abstract Daiichi Sankyo recently announced that Japan’s Ministry of Hea...

29 Mar

PEG & ADC

What is a fluorescent probe?

June 9, 2021
By axispharm

Fluorescence is a luminescence phenomenon of photoluminescence. When certain substances are excited by light, ele...

25 Mar

PEG & ADC

What is the click chemistry?

August 5, 2022
By axispharm

Click chemistry is a series of reactions proposed by K. Barry Sharpless, the winner of the Nobel Prize in Chemis...

22 Mar

PEG & ADC

Polyethylene Glycol Modification Reagent in Protein Medicine

June 9, 2021
By axispharm

Modified PEG is also called modified polyethylene glycol, which is a PEG-modified by a chemical modification grou...

16 Mar

PEG & ADC

What is cancer? How should we prevent it?

July 4, 2022
By axispharm

Cancer refers to malignant tumors originating from epithelial tissues and is the most common type of malignant t...

12 Mar

PEG & ADC

What is ADC(Antibody-drug Conjugates)?

July 14, 2022
By axispharm

Abstract ADCs combine the high specificity of monoclonal a...

10 Mar

PEG & ADC

What is PEG/PEG-linker？

June 28, 2022
By axispharm

Polyethylene glycol(PEG) is an ethylene glycol polymer with a relative molecular weight of 200 to 8000 or more t...

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