Biological Analysis

The tasks and research content of pharmacology

Pharmacology is a science that studies the interaction law between drugs and the body and the mechanism of drug action, mainly including pharmacodynamics and pharmacokinetics. The former is to elucidate the action and principle of the drug on the body, the latter to clarify the process of drug absorption, distribution, biotransformation and excretion in the body, as well as the law of drug effect and blood drug concentration with time.


The task of pharmacology
The disciplinary task of pharmacology is to provide theoretical basis for elucidating drug action and mechanism, improving drug quality, improving drug efficacy, and preventing adverse reactions; researching and developing new drugs, discovering new uses of drugs, and providing experimental data for exploring cell physiology, biochemistry and pathological processes. .

Pharmacological methods are experimental, that is, to observe the law of action of drugs on the body or its components under strictly controlled conditions and analyze its objective principle of action. Clinical pharmacology, which has gradually developed and established in recent years, is an applied science with clinical patients as research and service objects. Its task is to transform the basic theory of pharmacology into clinical medication technology, that is, to transform pharmacological effects into actual curative effects. Subsequent section.

The main purpose of studying pharmacology is to understand the role of drugs, their mechanism of action and how to give full play to their clinical efficacy. The three major tasks of pharmacology, or three categories:
First, pharmacology is a compulsory course in medical schools to guide clinical medication.
Second, evaluate the efficacy of the drug and how it differs from other aspects in terms of economy.
Third, pharmacology is an important part of life sciences.

There are two aspects here:
On the one hand, in addition to guiding clinical medication, drugs are usually used as tool drugs, which are further used in research, which greatly promotes academic development;
On the other hand, drug research itself is an important part of life science. I think that from the proportion of Nobel laureates, Nobel laureates account for more than 30% of pharmacology or drug laureates, which shows that pharmacology plays an important role in life sciences. For example, the pharmacological discoveries in the 1950s and 1990s have greatly improved human beings, and at the same time have greatly developed science.

Pharmacological research content
Pharmacology is a bridge discipline between basic medicine and clinical medicine, medicine and pharmacy. Clinical practice is carried out under the theoretical guidance of pharmacological science, and pharmacological theory is enriched on the basis of experimental research. In addition to respecting scientific laws, the research and application of drugs must also comply with laws, regulations and relevant guiding principles to protect people’s lives and health.

Pharmacological studies include:
1. Pharmacodynamics: Pharmacodynamics for short. Study the effect of drugs on the body, including the role and effect of drugs, mechanism of action and clinical application.
2, pharmacokinetics (pharmacokinetics): referred to as pharmacokinetics. Study the changes and laws of drugs under the action of the body, including the absorption, distribution, metabolism and excretion of drugs in the body, especially the laws of blood drug concentrations changing over time, and factors affecting drug efficacy.

AxisPharm is a San Diego based bioanalytical LC/MS/MS service provider with more than 25 years experience in the field. Our bioanalytical chemistry department specializes in developing and validating robust bioanalytical methods for PK/TK sample analysis of small molecules, proteins, peptides, and metabolites using LCMS/MS (HPLC, UPLC, on-line SPE), HPLC/UV, and HPLC/FL. We have experience analyzing API and metabolites in various biological matrices and can provide bioanalytical support throughout all the stages of drug development.

Method development
Method validation
Method transfer
Early discovery bioanalysis (non-GLP)
Sample Analysis
Discovery PK studies
Toxicokinetic studies
Pharmacology studies
Tissue distribution studies
Drug-drug interaction studies
BA/BE studies
AxisPharm Labs is well equipped with all the necessary tools and instruments to perform the following in vitro ADME tests.

Bioanalytical Service – PK Studies