t-Boc-N-Amido-PEG9-amine
This product is a bifunctional PEG9 linker with a Boc-protected amide and a terminal primary amine. The PEG9 spacer offers hydrophilicity, flexibility, and moderate chain length, while the Boc group provides acid-labile protection for controlled, orthogonal conjugation strategies.
Key Features and Benefits:
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Boc-Protected Amide: Provides acid-labile protection for stepwise, selective synthesis.
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Amine Group: Couples efficiently with carboxyls, NHS esters, and electrophiles.
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PEG9 Spacer: Ensures solubility, reduced steric hindrance, and balanced chain length.
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High Purity: Supports reproducibility in sensitive bioconjugation workflows.
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Orthogonal Reactivity: Enables multifunctional and selective conjugation.
Applications:
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Bioconjugation: Precise linker for attaching proteins, peptides, or small molecules.
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Drug Delivery: PEGylated linker improves solubility, stability, and pharmacokinetics.
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Surface Modification: Functionalizes nanoparticles, polymers, and hydrogels.
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Synthetic Chemistry: Useful intermediate in multistep PEGylated scaffold synthesis.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected environment.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain Boc and amine stability.
This product provides moderate PEG spacing with dual reactivity, making it an especially versatile reagent for orthogonal conjugation, bioconjugation, and advanced drug delivery strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
