DOTA-(t-Butyl)3-PEG5-azide
This product is a PEG-based chelator linker containing a DOTA core with three tert-butyl protecting groups, a PEG5 spacer, and a terminal azide. It specifically enables efficient copper-catalyzed or strain-promoted click chemistry and is widely used in probe development and radiolabeling.
Key Features and Benefits
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DOTA Core: Versatile macrocyclic chelator for radiometals and lanthanides.
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t-Butyl Protection: Stabilizes carboxyl groups during synthetic steps.
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Azide Group: Enables CuAAC or SPAAC click reactions with alkynes.
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PEG5 Spacer: Improves solubility and reduces steric hindrance.
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High Purity: Ensures reproducible results in chelation and conjugation workflows.
Applications
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Radiolabeling: Chelates metals such as Ga³⁺, Lu³⁺, and Cu²⁺ for PET/SPECT imaging.
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Bioconjugation: Links biomolecules through azide–alkyne click chemistry.
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Probe Development: Builds dual-functional probes for imaging and diagnostics.
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Drug Delivery: Serves as a scaffold for PEGylated, metal-binding conjugates.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates a protected DOTA chelator, a PEG5 spacer, and an azide group, specifically providing a versatile tool for radiolabeling, probe design, and multifunctional conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.