Mal-amido-PEG12-acid is a high-purity, heterobifunctional PEG linker featuring a maleimide group on one end and a carboxylic acid group on the other. With a 12-unit polyethylene glycol (PEG12) spacer, this compound offers excellent aqueous solubility, flexibility, and low immunogenicity, making it ideal for bioconjugation and drug delivery applications.
Key Features
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CAS Numbers: 2378428-27-2, 871133-36-7
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Molecular Structure: Maleimide–PEG12–COOH
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Functional Groups: Maleimide (thiol-reactive), Carboxylic acid (amine-reactive)
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Solubility: High in water and most polar solvents
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Form: White to off-white solid
Applications
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Bioconjugation of proteins, peptides, and antibodies
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Antibody-drug conjugates (ADCs)
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Surface modification of nanoparticles and biomaterials
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Targeted drug delivery systems
Chemical Reactivity
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The maleimide group reacts selectively with thiol (-SH) groups, forming stable thioether (C–S) bonds.
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The carboxylic acid group couples with amines under standard conditions (e.g., EDC, DCC, or HATU) to form amide bonds.
This dual reactivity enables site-specific labeling, crosslinking, and functionalization of biomolecules.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
