Mal-PEG1-Val-Cit-PAB-OH
Mal-PEG1-Val-Cit-PAB-OH is a high-purity cleavable PEG linker with a maleimide for thiol coupling, a cathepsin B–cleavable Val-Cit dipeptide, and a PAB spacer for payload release. Its short PEG1 spacer improves solubility and flexibility, ensuring stability in circulation and controlled intracellular release specifically for ADCs, targeted therapeutics, and diagnostic probes.
Key Features and Benefits
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds under mild conditions.
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Val-Cit Cleavable Linker: Stable in systemic circulation and cleaved by cathepsin B inside target cells.
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PAB Self-Immolative Spacer: Enables rapid and complete payload release after cleavage.
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PEG1 Spacer: Improves solubility and reduces steric hindrance without adding excess length.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
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Antibody–Drug Conjugates (ADCs): Link antibodies to cytotoxic drugs for targeted cancer therapy.
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Peptide–Drug Conjugates: Facilitate enzyme-triggered, site-specific drug release.
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Nanoparticle Functionalization: Introduce cleavable linkers for targeted delivery.
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Prodrug Development: Incorporate linkers that activate in disease-specific environments.
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Diagnostic Probe Development: Create imaging agents with controlled release capabilities.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve maleimide reactivity.
Mal-PEG1-Val-Cit-PAB-OH combines thiol-reactive maleimide chemistry with a cathepsin B–cleavable Val-Cit linker and PAB spacer, providing a stable yet triggerable system specifically for ADCs, targeted therapeutics, and diagnostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
