N,N-Bis(PEG1-azide)-N-amido-PEG2-maleimide
This product is a multifunctional linker featuring dual PEG1-azide groups for click chemistry and a maleimide group for thiol-specific conjugation. Its PEG-based design improves solubility and compact flexibility, making it especially effective for orthogonal bioconjugation, probe development, and drug delivery.
Key Features and Benefits:
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Dual Azide Groups: Enable CuAAC or SPAAC click chemistry with alkynes.
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Maleimide Group: Reacts selectively with thiols to form stable thioether bonds.
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PEG Spacers: Enhance solubility and reduce steric hindrance.
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Multifunctional Design: Supports orthogonal and stepwise conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioconjugation: Links thiol-containing biomolecules with azide-functional partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides dual-reactive PEGylated scaffolds for targeted release.
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Synthetic Chemistry: Serves as a versatile intermediate in linker design.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid maleimide hydrolysis before use.
This product integrates dual azides with thiol-reactive maleimide in a PEG scaffold, specifically offering multifunctional chemistry for advanced conjugation and therapeutic design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
