Tetrazine-SS-Biotin (CAS: 2123482-78-8)
Tetrazine-SS-Biotin is a cleavable linker designed for bioconjugation applications, including antibody-drug conjugates (ADCs) and protein labeling. It features a tetrazine group for bioorthogonal reactions and a biotin moiety for affinity tagging, connected via a disulfide bond that enables controlled cleavage under reductive conditions.
Key Features:
- Tetrazine Group:
- Reacts rapidly and selectively with trans-cyclooctene (TCO) groups via inverse electron demand Diels-Alder (iEDDA) chemistry.
- Ideal for bioorthogonal conjugation in complex systems.
- Disulfide Linkage:
- Provides a cleavable connection, allowing controlled release under reductive conditions.
- Biotin Moiety:
- Functions as an affinity tag for purification and detection.
Applications:
- Antibody-Drug Conjugates (ADCs):
- Links cytotoxic drugs to antibodies for targeted cancer therapies.
- Protein Labeling and Purification:
- Biotinylates proteins for affinity-based purification and detection.
- Bioorthogonal Chemistry:
- Enables site-specific conjugation in biological systems without disrupting native processes.
Tetrazine-SS-Biotin is a versatile and powerful tool in drug development and chemical biology, offering precision and flexibility for constructing complex bioconjugates.
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