Folate-PEG2-Mal is a bioconjugation reagent combining folic acid for targeted delivery to folate receptor-expressing cells, a PEG2 spacer for flexibility and solubility, and a maleimide (Mal) group for specific binding to thiol groups. Researchers commonly use it in targeted drug delivery, especially for cancer, where folate receptors frequently show overexpression.
Key Features:
- Folate Targeting: Binds selectively to folate receptors, aiding in targeted delivery to specific cells.
- PEG2 Spacer: Enhances solubility and flexibility, reducing steric hindrance during conjugation.
- Maleimide Group: Reacts efficiently with thiol groups, enabling stable attachment to biomolecules.
Applications:
- Targeted Drug Delivery: Conjugates drugs for delivery to folate receptor-positive cells, often used in cancer therapy.
- Bioconjugation: Links biomolecules like proteins and peptides in research and therapeutic applications.
- Nanoparticle Functionalization: Attaches nanoparticles to folate receptors for targeted diagnostics or therapies.
Storage:
Store in a cool, dry place, protected from light.
Folate-PEG2-Mal is valued in biomedical research for its selective targeting and compatibility with a wide range of conjugation applications, especially in cancer-focused studies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
