DBCO-PEG9-DBCO
DBCO-PEG9-DBCO is a high-purity homobifunctional PEG linker with dibenzocyclooctyne (DBCO) groups at both ends for rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) click chemistry. The PEG9 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling efficient crosslinking or conjugation of azide-functionalized biomolecules and materials in aqueous and organic systems. This reagent is especially ideal for bioconjugation, polymer modification, and nanoparticle functionalization.
Key Features and Benefits
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Dual DBCO Groups: Enable fast, catalyst-free SPAAC click reactions with azides.
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PEG9 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Homobifunctional Design: Supports crosslinking and multi-point conjugation strategies.
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High Purity: Supplied at >95% purity for reproducible performance.
Applications
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Crosslinking of azide-functionalized biomolecules.
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Polymer and hydrogel modification via click chemistry.
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Nanoparticle and surface functionalization.
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Bioconjugation in drug delivery and diagnostics.
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Multipoint labeling for biomaterials engineering.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain reactivity.
This product provides dual copper-free click handles connected by a PEG9 spacer, specifically offering solubility and flexibility for efficient crosslinking and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
