DBCO-PEG3-CH2CO-NHS ester
This product is a heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group for copper-free SPAAC click chemistry and an NHS ester for rapid amine coupling. The PEG3 spacer improves solubility and compact spacing, making it especially effective for dual-functional bioconjugation, probe design, and drug delivery.
Key Features and Benefits:
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DBCO Group: Enables catalyst-free SPAAC click reactions with azides.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG3 Spacer: Provides solubility, hydrophilicity, and steric accessibility.
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Dual Reactivity: Combines bioorthogonal and amine-targeted conjugation.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Bioconjugation: Links azide- and amine-containing biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds for targeted therapeutics.
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Material Science: Functionalizes polymers, nanoparticles, and advanced surfaces.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid NHS ester hydrolysis.
This product integrates bioorthogonal SPAAC reactivity with amine coupling in a PEG3 scaffold, specifically offering solubility and versatility for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
