4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzyl Bromide

4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzyl Bromide

Key Features and Benefits

• Photoreactive Diazirine: Generates reactive carbene species upon UV activation for covalent crosslinking.

• Benzyl Bromide Group: Alkylates nucleophiles such as thiols and amines for stable covalent modification.

• Dual-Reactive Design: Facilitates sequential capture and immobilization for advanced bioconjugation workflows.

• Broad Biomolecule Compatibility: Suitable for proteins, peptides, nucleic acids, and small molecules.

• High Purity: Supplied at >95% purity for reproducible and reliable results.

Applications

• Photoaffinity labeling in chemical biology.

• Mapping protein–protein and protein–ligand interactions.

• Target identification in proteomics.

• Immobilization of biomolecules on solid supports.

• Development of multifunctional probes.

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve benzyl bromide reactivity.

• Light Sensitivity: Minimize light exposure prior to UV activation to prevent premature reaction.

This product combines a UV-activated diazirine for covalent crosslinking with a benzyl bromide for nucleophile alkylation, specifically enabling versatile photoaffinity labeling, biomolecule immobilization, and proteomics applications.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.