Thiol-PEG-OH

Thiol-PEG-OH (HS-PEG-OH) is a linear heterobifunctional PEG with a thiol group at one end and a hydroxyl group at the other end. The thiol moiety can also react with a thiol-ene in the presence of a photoinitiator. The disulfide or olefin molecule reacts, and the terminal hydroxyl group (-OH) can be further derivatized into other molecules. Pegylation can increase the solubility and stability and reduce immunogenicity of peptides and proteins. It also inhibits the non-specific binding of charged molecules to the modified surface. Used in medical research, drug release, nanotechnology and new material research, cell culture.