LA-PEG-Mal(Lipoic acid-PEG-Maleimide) is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains a maleimide functional group (-NHCOCH=CH2) attached to the end of a PEG chain, with a lipoic acid molecule linked to the maleimide group via a spacer arm. The maleimide group is known for its ability to react with thiol groups (-SH) on other molecules, making Lipoic acid-PEG-Maleimide a useful tool in the field of pharmaceutical research and development.
Lipoic acid-PEG-Maleimide has been extensively utilized in the development of novel drug delivery systems, such as conjugates and targeted therapies. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via maleimide-thiol chemistry. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.
In addition to its use in drug delivery systems, Lipoic acid-PEG-Maleimide has also been employed as a surface modifier in various biomedical applications. For example, it can be immobilized onto the surface of medical devices or implants to improve biocompatibility and reduce immune response.
|LA-PEG-Mal, MW 3.4K
|LA-PEG-Mal, MW 5K