HO-PEG-Mal

HO-PEG-Mal contains a maleimide functional group (-Mal) at one end of the PEG chain, which allows for selective conjugation to thiol-containing molecules.

The maleimide functional group is widely used in bioconjugation chemistry due to its high reactivity towards thiol groups, such as those present in cysteine residues of proteins and peptides. By selectively conjugating HO-PEG-Mal to these thiol-containing molecules, it is possible to modify their physicochemical properties and improve their pharmacological profiles.

HO-PEG-Mal has been widely used in pharmaceutical research and development for the preparation of novel drug delivery systems, such as antibody-drug conjugates (ADCs) and protein therapeutics. The conjugation of HO-PEG-Mal to the thiol-containing molecules can improve their stability, solubility, and pharmacokinetic properties, leading to enhanced therapeutic efficacy and reduced side effects.