Lipoamide-PEG-Biotin (LA-PEG-Biotin or Lipoic Acid PEG Biotin) is a heterobifunctional PEG derivative. It links a lipoamide group for surface binding with a biotin group for strong affinity interactions. This makes it ideal for bioconjugation, surface modification, and nanoparticle functionalization in biomedical applications.
Lipoamide-PEG-Biotin
Lipoamide-PEG-Biotin, also called LA-PEG-Biotin or Lipoic Acid PEG Biotin, is a heterobifunctional PEG derivative with a lipoamide group at one end and a biotin group at the other.
Key Features:
- Structure: It combines a lipoamide group, which binds easily to gold or metal surfaces, with a biotin group that attaches strongly to streptavidin or avidin.
- Reactivity: The lipoamide anchors securely to surfaces like gold nanoparticles. Meanwhile, the biotin group binds tightly to avidin or streptavidin-conjugated molecules, making it ideal for targeted labeling and detection.
- Applications:
- Surface Modification: It coats gold or metal surfaces for use in biosensors and diagnostic tools.
- Bioconjugation: It links biotinylated molecules to metal surfaces for specific interactions.
- Nanoparticle Functionalization: It functionalizes gold nanoparticles for biomedical and analytical purposes.
- Solubility: The PEG chain ensures good water solubility and flexibility, boosting biocompatibility while minimizing non-specific binding.
Summary:
Lipoamide-PEG-Biotin (LA-PEG-Biotin or Lipoic Acid PEG Biotin) combines a lipoamide for surface binding with a biotin for strong affinity interactions. It works perfectly for bioconjugation, surface modification, and nanoparticle functionalization in biosensing and biomedical fields.