DBCO-PEG-Silane

DBCO-PEG-Silane is a versatile linear heterobifunctional PEG reagent that combines DBCO (dibenzocyclooctyne) and silane functionalities. This innovative compound is ideal for crosslinking and bioconjugation, offering efficient surface modification and chemical conjugation solutions.

Key Features:

• Linear Heterobifunctional Reagent: Features a DBCO group and a silane group linked by a PEG spacer, facilitating flexible and effective bioconjugation and surface functionalization.
• DBCO (Dibenzocyclooctyne): Supports copper-free click chemistry through strain-promoted 1,3-dipolar cycloaddition with azide-containing molecules. This bioorthogonal reaction allows for clean and efficient conjugation in aqueous solutions without metal catalysts.
• PEG Spacer: Enhances solubility, stability, and flexibility, reducing non-specific binding and improving performance in biological and chemical environments.
• Silane Functional Group: Provides strong adhesion to various surfaces, making it perfect for durable and effective surface modification.

Applications:

• Surface Modification: Ideal for modifying surfaces such as glass and silicon in biosensors, microarrays, and diagnostic devices. The silane group ensures strong, stable attachment to a variety of substrates.
• Bioconjugation: Facilitates precise labeling of azide-modified biomolecules using Cu-free click chemistry, making it suitable for drug delivery, imaging, and therapeutic applications.
• Crosslinking: Useful for creating crosslinked networks in materials and polymers, enhancing their mechanical and chemical properties.
• Lab-on-a-Chip Devices: Enhances the performance of lab-on-a-chip devices by providing a stable and adaptable surface for various biochemical assays.