Biotin-PEG-SVA

Biotin-PEG-SVA is a bifunctional molecule that contains both a biotin moiety and a reactive N-hydroxysuccinimide ester (SVA) group attached to a PEG chain. The biotin moiety is known for its high affinity to streptavidin, a protein widely used in biotechnology, while the SVA group allows for the covalent attachment of biotin-PEG-SVA to other molecules.

Biotin-PEG-SVA is often used as a tool for protein and antibody purification, as well as for the development of diagnostic assays. Its unique chemical properties enable the selective binding of streptavidin to biotin-PEG-SVA conjugates, allowing for the isolation and purification of biotinylated proteins or antibodies. Additionally, the SVA group can be utilized to covalently attach biotin-PEG-SVA to solid supports, such as microplates or beads, for the development of diagnostic assays.

Biotin-PEG-SVA has also been employed in the design and development of drug delivery systems. Its biotin moiety can be conjugated to drugs, proteins or peptides, while its PEG chain imparts improved solubility, stability, and biocompatibility to the resulting conjugates. This has led to the development of novel targeted drug delivery systems with enhanced efficacy and reduced toxicity.