Azide-PEG-Silane (N3-PEG-Silane) is a linear heterobifunctional PEG reagent with an azide group and an amine group at both ends, respectively, CuAAC reacts with terminal alkyne or SPAAC reacts with cyclooctyne The (DBCO/BCN) reaction forms a covalent triazole bond. Silanes are surface modifying groups that react with hydroxyl groups on the surface of glass, nanoparticles, etc. They have broad applications in medical devices, biomes, or biocompatible material development.