OPSS-PEG-Amine

OPSS-PEG-Amine(Ortho-Pyridyldisulfide-PEG-Amine) comprises three distinct functional groups:OPSS features a disulfide bond (S-S) and an aromatic pyridine ring. The disulfide bond enables reversible and selective cleavage under reducing conditions, providing controlled release in biological systems. The pyridine ring imparts enhanced stability and reactivity.PEG is biocompatible, water-soluble polymer, the process of attaching PEG to molecules, improves solubility, stability, and circulation time, reducing immunogenicity and proteolytic degradation.NH2 composed of a nitrogen atom bonded to two hydrogen atoms, facilitates conjugation with various biomolecules through well-established chemistries, such as amide bond formation.

applications in medicine

Drug delivery: OPSS-PEG-Amine can be used to design targeted, stimuli-responsive drug delivery systems. The reversible disulfide bond allows for controlled drug release in the presence of intracellular reducing agents, while the PEG moiety enhances solubility and biocompatibility.

Surface modification: OPSS-PEG-Amine can functionalize surfaces for medical implants, biosensors, and diagnostic devices. The PEG segment promotes resistance to protein adsorption and cell adhesion, reducing biofouling and the foreign body response.

Bioconjugation: OPSS-PEG-Amine serves as a linker for conjugating biomolecules, such as antibodies, proteins, and peptides. This enables the development of targeted therapeutics, imaging agents, and bioactive materials with improved pharmacokinetics and reduced immunogenicity.