m-PEG-NHS ester

m-PEG-NHS ester is a polymer that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains an N-hydroxysuccinimide (NHS) ester functional group, which is known for its ability to react with amino groups (-NH2) of proteins and peptides, making it a useful tool in the field of pharmaceutical research and development.

m-PEG-NHS ester has been extensively utilized in the development of protein and peptide conjugates. Its unique chemical properties allow for the covalent attachment of therapeutic agents to the PEG chain via amide bonds. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.

In addition to its use in protein and peptide conjugation, m-PEG-NHS ester has also been employed as a surface modifier in various biomedical applications. For example, it can be immobilized onto the surface of medical devices or implants to improve biocompatibility and reduce immune response.