4arm-PEG-SC

4arm-PEG-SC is a polyethylene glycol (PEG) derivative that contains four arms or branches, each with a reactive succinimidyl carbonate (SC) functional group. The SC group is known for its ability to react with primary amines, forming stable carbamate linkages.

4arm-PEG-SC has been widely utilized in the development of various drug delivery systems, including conjugation with proteins, peptides, and small molecules. Its unique chemical properties allow for the conjugation of therapeutic agents to the PEG chain via the carbamate bond, resulting in increased stability, solubility, and reduced immunogenicity.

4arm-PEG-SC has been employed as a surface modifier in the development of biomaterials, such as hydrogels and nanoparticles. The reactive SC groups on the PEG chain can be utilized to covalently link the PEG to the surface of the biomaterials, leading to improved biocompatibility, reduced protein adsorption, and enhanced drug release properties.