S-acetyl-PEG-t-butyl ester contains an acetyl functional group attached to the sulfur atom of a PEG chain and a t-butyl ester group at the other end.
S-acetyl-PEG-t-butyl ester has been extensively utilized in the development of novel drug delivery systems, such as conjugates and prodrugs. The acetyl group at one end of the PEG chain can be used as a site for chemical modification, such as conjugation with therapeutic agents or targeting ligands. The t-butyl ester group at the other end provides a temporary protective group that can be easily removed under mild conditions to expose a free carboxylic acid group, which can then be used for further conjugation or activation.
S-acetyl-PEG-t-butyl ester is also used as a surface modifier in various biomedical applications. For instance, it can be attached to the surface of nanoparticles or medical devices to improve their biocompatibility and reduce their immunogenicity.