S-acetyl-PEG-alcohol contains an alcohol functional group (-OH) attached to a PEG chain via an S-acetyl linkage (-O-C(=O)-CH3). The acetyl group can be easily removed under mild conditions, making S-acetyl-PEG-alcohol a useful tool in the field of pharmaceutical research and development.
S-acetyl-PEG-alcohol has been extensively utilized in the development of novel drug delivery systems, such as liposomes, micelles, and dendrimers. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as drugs, peptides, and proteins, to the PEG chain via ester or amide bonds. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.
S-acetyl-PEG-alcohol has been used as a linker in antibody-drug conjugates (ADCs). ADCs are a promising class of biopharmaceuticals that combine the selectivity of monoclonal antibodies with the cytotoxicity of small molecule drugs. S-acetyl-PEG-alcohol serves as a flexible and biocompatible linker that can facilitate the attachment of a drug payload to an antibody without compromising its binding specificity and affinity.