M-PEG-S-Acetyl contains an acetyl functional group (-COCH3) attached to a thiol group (-SH) on the middle carbon atom of a PEG chain. The thiol group is known for its ability to react with other molecules through disulfide bond formation, while the acetyl group is known for its ability to modify the surface charge of biomolecules.
M-PEG-S-Acetyl has been extensively utilized in the field of pharmaceutical research and development, specifically in the development of targeted drug delivery systems. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via disulfide bonds. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.
Furthermore, the acetyl group in M-PEG-S-Acetyl can also modify the surface charge of biomolecules, allowing for the attachment of targeting moieties such as antibodies or peptides. This targeted drug delivery approach can improve drug efficacy and reduce off-target side effects.