Propargyl-PEG-alcohol(Alkyne-PEG-alcohol） contains an alcohol functional group (-OH) and a propargyl group (-C≡CH) attached to the ends of a PEG chain.
Propargyl-PEG-alcohol has been widely used in the development of drug delivery systems, particularly for the conjugation of therapeutic agents such as proteins and peptides. The propargyl group allows for the selective conjugation of bioactive molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC), also known as click chemistry. This reaction provides a stable and bio-orthogonal linkage between the PEG and the therapeutic agent, resulting in improved stability and prolonged circulation time in vivo.
The alcohol functional group of Propargyl-PEG-alcohol also offers additional opportunities for chemical modification, such as the conjugation of small molecules or imaging probes. This allows for the development of multifunctional drug delivery systems with potential applications in disease diagnosis, imaging, and therapy.
