A valine-glycine linker is a type of peptide linker widely used in the design of antibody-drug conjugates (ADCs). These linkers are composed of a valine and glycine sequence.
Valine-glycine linkers are known for their stability in the bloodstream, which helps maintain the integrity of the drug conjugate until it reaches the target. Valine-glycine linkers can be designed to be cleaved by specific enzymes present in the target cancer cells, ensuring that the drug is released only at the desired location. This targeted delivery and controlled release of the drug by using valine-glycine linkers helps minimize the systemic toxicity and side effects associated with the therapeutic agents and improve the therapeutic efficacy of the drug by ensuring that a higher concentration of the active agent reaches the target cells.
