Ald-CH2-PEG-NHBoc is a chemical compound that has gained significant interest in the field of pharmaceutical research and development. It belongs to the family of PEGylated compounds and is a derivative of PEG (polyethylene glycol), which is a water-soluble polymer. The compound consists of an aldehyde group (Ald), a polyethylene glycol (PEG) chain, and a Boc-protected amine group (NHBoc).
The PEGylation process involves the covalent attachment of PEG to a biologically active molecule, such as a protein, peptide, or drug, to improve its pharmacokinetic and pharmacodynamic properties. PEGylation can increase the half-life of a drug, reduce its immunogenicity, and improve its solubility and stability, among other benefits.
Ald-CH2-PEG-NHBoc is often used as a linker molecule in the synthesis of PEGylated drugs and is particularly useful in the preparation of antibody-drug conjugates (ADCs), which are a promising class of targeted cancer therapies. The aldehyde group of Ald-CH2-PEG-NHBoc can react with the primary amine group of the antibody, while the Boc-protected amine group can react with the drug molecule, allowing for the controlled conjugation of the drug to the antibody.
Ald-CH2-PEG-NHBoc
Cat# | Name | Structure | Pricing |
---|---|---|---|
AP10071 | Ald-CH2-PEG2-NHBoc | Pricing | |
AP10070 | Ald-CH2-PEG3-NHBoc | Pricing | |
AP10072 | Ald-CH2-PEG4-NHBoc | Pricing |