M-PEG-thiol(M-PEG-SH) is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains a thiol functional group (-SH) attached to the middle carbon atom of a PEG chain. The thiol group is known for its ability to react with other molecules through disulfide bond formation, making M-PEG-thiol a useful tool in the field of pharmaceutical research and development.
M-PEG-thiol has been extensively utilized in the development of novel drug delivery systems, such as micelles, liposomes, and nanoparticles. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via disulfide bonds. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.
In addition to its use in drug delivery systems, M-PEG-thiol has also been employed as a surface modifier in various biomedical applications. For example, it can be immobilized onto the surface of medical devices or implants to improve biocompatibility and reduce immune response.