Isothiocyanato-PEG-Alcohol is a functional group that has gained significant attention in drug research and development. It is a chemical compound consisting of an isothiocyanate group, a polyethylene glycol (PEG) linker, and an alcohol functional group. The isothiocyanate group is a reactive moiety that can be easily modified to bind to various target molecules, making it a valuable tool in drug development.
The PEG linker in Isothiocyanato-PEG-Alcohol plays a crucial role in enhancing the compound’s solubility and stability, which are important factors in drug design. PEGylation of drug molecules has been shown to improve their pharmacokinetic properties, including prolonged circulation time, reduced immunogenicity, and increased bioavailability.
Isothiocyanato-PEG-Alcohol has found extensive use in the development of targeted drug delivery systems, such as antibody-drug conjugates (ADCs) and polymer-drug conjugates. ADCs are a class of therapeutics that combine the specificity of monoclonal antibodies with the cytotoxicity of small molecule drugs. The isothiocyanate group in Isothiocyanato-PEG-Alcohol can be conjugated to the antibody, allowing for the targeted delivery of the drug to specific cells or tissues.
Isothiocyanato-PEG-Alcohol
| Cat# | Name | Structure | Pricing |
|---|---|---|---|
| AP11284 | 1-isothiocyanato-PEG4-Alcohol | Pricing |
