Folate-PEG-NHS Ester (Folic Acid-PEG-NHS Ester) targets cancer cells with folate receptors. It enhances solubility and stability. It links drugs, antibodies, or peptides, boosting efficacy and reducing off-target effects.
Folate-PEG-NHS ester
| Cat# | Name | Structure | Pricing |
|---|---|---|---|
| AP10011 | Folate PEG3 NHS ester | Pricing | |
| AP15300 | Folate PEG10 NHS ester | Pricing |
Folate-PEG-NHS Ester (Folic Acid-PEG-NHS Ester)
Folate-PEG-NHS Ester is a versatile compound widely used in drug research and development. It combines the essential B vitamin folate, a polyethylene glycol (PEG) spacer, and an NHS ester functional group, making it a powerful tool for targeted drug delivery and bioconjugation.
Key Features:
- Folic Acid Moiety:
- Derived from folate, essential for DNA synthesis and cellular processes.
- Targets cancer cells that overexpress folate receptors for precise drug delivery.
- PEG Spacer:
- Improves solubility, stability, and biocompatibility.
- Reduces immunogenicity and prolongs circulation time in the body.
- NHS Ester Functional Group:
- Reacts efficiently with primary amines under mild conditions.
- Facilitates conjugation to drugs, proteins, antibodies, or peptides.
Applications:
- Targeted Drug Delivery:
- Used for folate receptor-mediated targeting in cancer therapy.
- Improves drug efficacy and specificity while minimizing off-target effects.
- Bioconjugation:
- Serves as a linker molecule to attach drugs to targeting agents like antibodies or peptides.
- Enhances drug selectivity and binding affinity to intended targets.
- Diagnostic Imaging:
- Conjugated with imaging agents for tumor visualization in cancers with high folate receptor expression.
Benefits:
- Enhanced Selectivity:
- Directs therapeutic agents to folate receptor-expressing cells, common in many cancers.
- Reduced Toxicity:
- Minimizes off-target effects by focusing delivery to intended sites.
- Improved Biocompatibility:
- PEG spacer ensures better solubility and reduced immunogenicity.
Folate-PEG-NHS Ester is a critical component in modern drug research, offering advanced capabilities for targeted therapies, diagnostics, and bioconjugation. Its ability to combine selective targeting with enhanced stability and flexibility makes it an invaluable tool for innovative biomedical applications.