Modified Triphosphates

Modified triphosphates are a class of molecules that are widely used in various applications, including molecular biology, genetics, and drug discovery. They are a type of nucleotide analog that has been modified to contain a functional group or chemical moiety, which can impart specific properties or functions to the molecule.

It can be broadly classified into several categories based on their structural features and applications. One such category is labeled triphosphates, which are modified with fluorescent or biotin labels, and are used in DNA sequencing, labeling, and detection assays. Another category is caged triphosphates, which are modified with photolabile groups that can be activated by light, enabling precise temporal and spatial control of nucleic acid synthesis.