Tetrazine-Ph-SS-amine is a cleavable linker designed for targeted drug delivery and bioconjugation. It features a tetrazine group for bioorthogonal reactions with strained alkenes like trans-cyclooctene (TCO) via inverse electron demand Diels-Alder (iEDDA) chemistry. The disulfide bond (SS) enables controlled release under reducing conditions, making it perfect for antibody-drug conjugates (ADCs).
Key Features:
- Tetrazine Group: Enables fast, selective iEDDA reactions with TCO-containing molecules.
- Disulfide Bond (SS): Provides cleavable linkage under reducing conditions, allowing for controlled payload release.
- Amine Functionality: Facilitates coupling with carboxyl groups or activated esters for further modifications.
Applications:
- Antibody-Drug Conjugates (ADCs): Links drugs to antibodies for targeted cancer therapy.
- Bioconjugation: Efficiently attaches biomolecules with controlled release.
- Chemical Biology Research: Supports site-specific labeling and protein interaction studies.
This linker ensures precise molecular assembly, controlled drug release, and efficient bioconjugation. It is valuable in therapeutic development and biomedical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
