TCO-PEG1-Val-Cit-OH
This product is a cleavable PEG-based linker containing a trans-cyclooctene (TCO) group, a PEG1 spacer, and a Val-Cit dipeptide with a terminal hydroxyl group. It specifically enables rapid tetrazine click reactions and provides enzyme-cleavable functionality for drug delivery and bioconjugation.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via inverse-electron-demand Diels–Alder (IEDDA) click chemistry.
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PEG1 Spacer: Improves solubility and reduces steric hindrance.
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Val-Cit Motif: Enzyme-cleavable sequence widely used in drug-linker design.
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Hydroxyl Group: Provides versatile functionality for further derivatization.
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High Purity: Ensures reproducibility in drug conjugation and research applications.
Applications
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Antibody–Drug Conjugates (ADCs): Functions as a cleavable linker in targeted therapeutics.
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Bioconjugation: Links biomolecules through TCO–tetrazine click chemistry.
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Drug Delivery: Enables enzyme-triggered release of active agents.
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Probe Development: Builds responsive probes for imaging and diagnostics.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to preserve reactivity.
This product integrates TCO click reactivity with an enzyme-cleavable Val-Cit motif and a hydroxyl group, specifically offering a versatile building block for ADCs, drug delivery, and responsive probes.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
