Propargyl-PEG2-azide
This product is a high-purity heterobifunctional PEG linker with a terminal alkyne specifically for copper-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry and an azide for either CuAAC or strain-promoted azide–alkyne cycloaddition (SPAAC). The PEG2 spacer improves solubility, flexibility, and reduces steric hindrance, enabling especially efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Propargyl Group – Supports CuAAC click chemistry with azide-containing molecules for stable triazole formation.
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Azide Group – Enables CuAAC or SPAAC click chemistry for catalyst-dependent or catalyst-free conjugation.
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PEG2 Spacer – Enhances solubility, flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Allows sequential, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reliable and reproducible performance.
Applications
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Dual-functional linker for orthogonal bioconjugation
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Protein, peptide, and small molecule modification
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Click chemistry-based probe and sensor synthesis
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Multifunctional drug delivery systems
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Biomolecule labeling for imaging and diagnostics
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture to maintain reactivity
This product is a short, high-purity PEG linker combining a propargyl group for CuAAC and an azide for CuAAC or SPAAC, connected by PEG2 for solubility and flexibility, enabling especially efficient orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
