Chemical probes for the BRPF bromodomain and BRPF3 are scaffold proteins. PFI 4 specifically binds to BRPF1B with IC50 = 172 nM and Kd = 13 nM, determined by ITC. PFI 4 shortens the recovery time of triple BRD cell constructs in FRAP and is potent in cells with IC50 250nM, with no effect on BRPF1A. PFI 4 is more than 100-fold selective for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.
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![N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine](https://e1752fbe.rocketcdn.me/wp-content/uploads/AP14270-CAS-231278-20-9-1-e1686064939791.png)
