Mal-PEG-HZ, MW 2K(Maleimide-PEG-Hydrazide) contains two functional groups: a maleimide group and a hydrazide group (-NH-NH2) attached to the opposite ends of a PEG chain.
The maleimide group can react with free thiol groups on the surface of proteins, allowing for the site-specific conjugation of PEG chains to the protein of interest. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
