Mal-NHS ester
This product is a heterobifunctional crosslinker containing a maleimide group and an N-hydroxysuccinimide (NHS) ester. It enables selective thiol conjugation via the maleimide group and efficient amine coupling through the NHS ester, making it an especially versatile bioconjugation reagent.
Key Features and Benefits
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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NHS Ester: Reacts efficiently with primary amines for amide bond formation.
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Dual Reactivity: Enables orthogonal conjugation of thiol- and amine-containing molecules.
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Compact Design: Provides minimal steric hindrance for efficient crosslinking.
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High Purity: Ensures reliable and reproducible conjugation results.
Applications
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Bioconjugation: Links proteins, peptides, and other biomolecules via thiol and amine groups.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Constructs dual-functional scaffolds for therapeutic conjugates.
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Material Science: Functionalizes polymers and nanoparticles with orthogonal handles.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product combines thiol-selective and amine-reactive chemistry in a compact linker, making it an especially powerful tool for bioconjugation, probe design, and advanced material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
