Fmoc-D-Lys-(biotin-PEG12)-OH

Fmoc-D-Lys(biotin-PEG12)-OH: Advanced Peptide Reagent for Cutting-Edge Applications

Overview

Fmoc-D-Lys(biotin-PEG12)-OH is a high-performance reagent designed for advanced peptide synthesis and bioconjugation. Combining the Fmoc protection strategy with biotinylation and a PEG12 spacer, this compound facilitates the creation of stable, soluble, and highly functional peptide-based products. Ideal for researchers and developers in peptide chemistry, bioconjugation, and assay development, Fmoc-D-Lys(biotin-PEG12)-OH enhances the precision and effectiveness of your experiments.

Key Features

• Fmoc Protection: Ensures efficient and selective peptide synthesis with high purity and yield. The Fmoc group can be easily removed, making it ideal for iterative synthesis processes.
• D-Lysine Residue: Offers unique advantages in peptide applications, including altered peptide stability and resistance to enzymatic degradation.
• Biotinylation: Provides a strong and specific binding affinity to streptavidin or avidin, enabling precise detection, purification, and targeting.
• PEG12 Spacer: Enhances solubility and reduces non-specific interactions, ensuring improved performance in complex biological systems.

Applications

1. Peptide Synthesis: Incorporate biotinylated D-lysine into peptides for generating high-value peptide libraries, labeled constructs, and functionalized peptides.
2. Assay Development: Utilize the biotin-PEG12 tag for creating robust assays such as ELISA, western blotting, and immunoassays with improved signal strength and stability.
3. Therapeutic Development: Design peptide-based therapeutics with enhanced solubility and targeted delivery, utilizing biotinylation for efficient tracking and monitoring.

Benefits

• Enhanced Stability: PEGylation improves the stability of biotinylated peptides, allowing for more reliable performance in biological settings.
• Improved Solubility: The PEG12 spacer increases aqueous solubility, minimizing issues related to peptide aggregation and precipitation.
• High Specificity: The biotin-avidin interaction provides superior specificity in detection and purification applications, crucial for accurate results.

Ref: Sato, A., Fukase, T. and Ebina, K., 2022. Biotinylated peptides substituted with D‐amino acids with high stability as anti‐anaphylactic agents targeting platelet‐activating factor. Journal of Peptide Science, 28(10), p.e3412.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.