endo-BCN-PEG3-acid
endo-BCN-PEG3-acid is a PEG linker containing an endo-bicyclo[6.1.0]nonyne (BCN) group, a PEG3 spacer, and a terminal carboxylic acid. It enables copper-free click chemistry with azides and amide coupling, offering dual functionality in a compact scaffold.
Key Features and Benefits
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Endo-BCN Group: Reacts rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).
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Carboxylic Acid: Couples efficiently with primary amines to form stable amide bonds.
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PEG3 Spacer: Improves solubility while maintaining compact molecular length.
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Dual Reactivity: Combines copper-free click chemistry with carboxyl coupling.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links azide-modified molecules with amine-containing partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with click and amide handles.
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Material Science: Functionalizes nanoparticles, surfaces, and polymers with dual-reactive groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates bioorthogonal BCN click chemistry with carboxyl reactivity in a PEG3 scaffold, specifically offering a compact, soluble, and versatile linker.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
