DBCO-PEG3-CH2CO2H CAS:2249926-65-4 contains two functional groups, a carboxylic acid (-CO2H) and a cyclooctyne moiety (-DBCO) attached to the end of a PEG chain through a short linker.
DBCO-PEG3-CH2CO2H is a popular building block for DBCO derivatization. The acid group can react with amine to form amide bond under coupling conditons in the presence of activators such as EDC, DCC and HATU. DBCO. On the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-PEG3-CH2CO2H has been widely utilized in the development of novel imaging probes, drug delivery systems, and theranostics. Its bioorthogonal click chemistry reactivity and the ability to introduce targeting ligands or therapeutic agents have been exploited for selective delivery of drugs or imaging agents to specific cells or tissues, improving the efficacy and reducing the toxicity of the treatments.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
