DBCO-NH-PEG7-acid contains a dibenzocyclooctyne (DBCO) functional group, an amine group (-NH2), and a carboxylic acid group (-COOH) attached to a PEG chain of seven repeating units.
The DBCO functional group is known for its ability to undergo rapid and efficient click chemistry reactions with azide-containing molecules, allowing for the facile conjugation of biomolecules, such as proteins and peptides, to the PEG chain. The amine group can also be used to conjugate molecules through traditional amide bond formation, while the carboxylic acid group can be activated with coupling agents, such as N-hydroxysuccinimide (NHS), to enable the formation of peptide bonds.
DBCO-NH-PEG7-acid has been extensively utilized in the development of novel drug delivery systems, such as micelles, liposomes, and nanoparticles. Its unique chemical properties allow for the conjugation of therapeutic agents to the PEG chain via covalent bonds, leading to improved stability, increased solubility, and prolonged circulation time in vivo. Furthermore, the use of click chemistry reactions enables the precise control of the drug-to-carrier ratio, which is critical for optimizing therapeutic efficacy and reducing toxicity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
