DBCO-NH-PEG3-acid contains a carboxylic acid functional group (-COOH) and an azide-reactive DBCO (dibenzocyclooctyne) group. The PEG3 spacer between these functional groups provides flexibility and hydrophilicity to the molecule.
DBCO-NH-PEG3-acid is a popular building block for DBCO derivatization. The acid group can react with amine to form amide bond under coupling conditons in the presence of activators such as EDC, DCC and HATU. DBCO. On the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NH-PEG3-acid is widely used in pharmaceutical research and development for the design and optimization of drug delivery systems. The azide-reactive DBCO group allows for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via click chemistry. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
